Anti-Neutrophil Bactericidal Protein BP30 antibody (ab101862)

Overview

• Product nameAnti-Neutrophil Bactericidal Protein BP30 antibody
• Description
  Rabbit polyclonal to Neutrophil Bactericidal Protein BP30
• Tested applicationsWB, IHC-P, IHC-Fr more details
• Species reactivity
  Reacts with: Human
  
• Immunogen

  A synthetic peptide from the N terminal region of Human Neutrophil Bactericidal Protein BP30 conjugated to an immunogenic carrier protein.

Properties

• FormLiquid
• Storage instructionsStore at +4°C short term (1-2 weeks). Add glycerol to a final volume of 50%, aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.
• Storage bufferPreservative: None
  Constituents: Whole serum
• PurityWhole antiserum
• Clonality Polyclonal
• IsotypeIgG
• Research Areas
  • Cardiovascular
  • Blood
  • Other

  • Microbiology
  • Antimicrobial
  • Antibiotic

  • Immunology
  • Innate Immunity
  • Macrophage / Inflamm.

  • Immunology
  • Immune System Diseases
  • Autoimmune

Applications

Target

• FunctionThe cytotoxic action of BPI is limited to many species of Gram-negative bacteria; this specificity may be explained by a strong affinity of the very basic N-terminal half for the negatively charged lipopolysaccharides that are unique to the Gram-negative bacterial outer envelope. Has antibacterial activity against the Gram-nagative bacterium P.aeruginosa, this activity is inhibited by LPS from P.aeruginosa.
• Tissue specificityRestricted to cells of the myeloid series.
• Sequence similaritiesBelongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.
• DomainThe N-terminal region may be exposed to the interior of the granule, whereas the C-terminal portion may be embedded in the membrane. During phagocytosis and degranulation, proteases may be released and activated and cleave BPI at the junction of the N-and C-terminal portions of the molecule, providing controlled release of the N-terminal antibacterial fragment when bacteria are ingested.
• Cellular localizationSecreted. Cytoplasmic granule membrane. Membrane-associated in polymorphonuclear Leukocytes (PMN) granules.

Target information above from: UniProt accession P17213 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010) .

Information by UniProt
• Database links
  • Entrez Gene: 671 Human
  • Omim: 109195 Human
  • SwissProt: P17213 Human
  • Unigene: 529019 Human

• Alternative names
  Bactericidal permeability-increasing protein antibodyBactericidal/permeability increasing protein antibodyBPI antibody

  BPI_HUMAN antibodyCAP 57 antibodyCAP57 antibody

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