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AbcamBiochemicals (Asc-531)

Nicardipine hydrochloride (ab120531)

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Overview

  • Product nameNicardipine hydrochloride
  • Description
    L-type Ca2+ channel antagonist
  • Biological descriptionSelective, L-type Ca2+ channel blocker (IC50 = 24.1 μM). Dihydropyridine derivative. Potent coronary and cerebral vasodilator.
  • Purity> 99%

    • Properties

  • Chemical name1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)methyl-2-[methyl(phenylmethyl)amino]-3,5-pyridinedicarboxylic acid ethyl ester hydrochloride
  • Molecular Weight515.99
  • Chemical structureChemical Structure
  • Molecular formulaC26H29N3O6.HCl
  • CAS Number54527-84-3
  • Storage instructionsStore at +4°C (desiccating conditions).
  • Handling

    Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 6 months.

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

  • Source

    Synthetic

  • Research Areas

    • References for Nicardipine hydrochloride (ab120531)

    This product has been referenced in:
    • Yui H  et al. Comparative effects of verapamil, nicardipine, and nitroglycerin on myocardial ischemia/reperfusion injury. Anesthesiol Res Pract 2011:521084 (2011). Read more (PubMed: 21403860) »
    • Furukawa T  et al. Selectivities of dihydropyridine derivatives in blocking Ca(2+) channel subtypes expressed in Xenopus oocytes. J Pharmacol Exp Ther 291:464-73 (1999). Read more (PubMed: 10525060) »
    • Endo T  et al. Comparative effects of nicardipine, a new calcium antagonist, on size of myocardial infarction after coronary artery occlusion in dogs. Circulation 74:420-30 (1986). Read more (PubMed: 3731430) »

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"