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Product Name
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Nicotinic Acetylcholine Receptor alpha 1 antibody [61]
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See all Nicotinic Acetylcholine Receptor alpha 1 antibodies (3)...
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Product type
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Primary antibodies
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Description
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Rat monoclonal [61] to Nicotinic Acetylcholine Receptor alpha 1
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Immunogen
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Denatured Electophorus electricus acetylcholine receptors (AChRs).
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Reacts with
(species key)
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Hu, Ms, Trpd
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Specificity
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ab24631 reacts with Neuronal Nicotinic Acetylcholine Receptor a1-Subunits.
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Epitope
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This antibody binds to the cytoplasmic surface of native and denatured muscle AChR a1 subunits, within amino acids 371-386.
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Tested applications
(see key)
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ICC/IF, IP
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Abreviews
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Application notes
(see key)
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Recommended dilutions
IF: 1/250 - 1/500. IP: 1/100.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
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Cellular localization
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Cell Membrane
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Research areas
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Neuroscience >> Neurotransmission >> Receptors / Channels >> Ligand-Gated Ion Channels >> nAch Receptors
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Relevance
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After binding acetylcholine, Nicotinic Acetylcholine Receptor alpha 1 responds by an extensive change in conformation that affects all subunits and leads to opening of an ion conducting channel across the plasma membrane. Isoform 1 is only expressed in skeletal muscle whereas isoform 2 is constitutively expressed in skeletal muscle, brain, heart, kidney, liver, lung and thymus
ab24631 is useful in studying AChR synthesis and assembly.
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Database links
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The links below go to external sites and will open in a new browser window |
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Raised in
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Rat
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Clonality
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Monoclonal
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Clone number
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61
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Isotype
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IgG2a
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Purity
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Ascites
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Storage buffer
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Preservative: None
Constituents: Ascites
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Form
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Liquid
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Concentration
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4.000 mg/ml
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Storage instructions
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Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
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At Abcam, we have one centralized database to hold all of our product information, so that everything we know about this Nicotinic Acetylcholine Receptor alpha 1 antibody [61] is on this datasheet. But please do contact us if you would like any reassurance! |
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References for Nicotinic Acetylcholine Receptor alpha 1 antibody [61] (ab24631)
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This product has been used in:
Tzartos SJ et al. Mapping of surface structures of electrophorus acetylcholine receptor using monoclonal antibodies. J Biol Chem 256:8635-45 (1981). PubMed: 6167581
If you publish research using ab24631 please let us know so that we can cite the reference on this datasheet.
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Search PubMed (MEDLINE) for references to Nicotinic Acetylcholine Receptor alpha 1
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Nicotinic Acetylcholine Receptor alpha 1 antibody [61] - more information
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Protocols for Nicotinic Acetylcholine Receptor alpha 1 antibody [61] |
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