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Product name
Nigericin Na+ salt
Description
K+ ionophore
Biological description
K+ ionophore; exchanges K+ for H+ across most biological membranes. Stimulates mitochondrial ATPase activity, and exchanges H+ for K+>Rb+>Cs+>>Na+. Reported to inhibit poliovirus and influenza virus replication.
Purity
> 98%
General notes
Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 6 months.
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one week. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Country restrictions and/or license requirements may apply. Please contact customer services for further details.
Properties
Chemical name
Nigericin sodium salt
Molecular Weight
746.95
Chemical structure
Molecular formula
C40H67NaO11
CAS Number
28643-80-3
Solubility
Soluble in ethanol to 100 mM
Storage instructions
Store at +4°C (desiccating conditions). Do not freeze.
Research areas
Biochemicals >> Pharmacology >> Enzymes >> ATPase & GTPase >> Activators
Biochemicals >> Pharmacology >> Ion Channels >> Ionophores
Biochemicals >> Chemical Type >> Biochemicals
References for Nigericin Na+ salt (ab120494)
This product has been referenced in:
- Myskiw C et al. Nigericin is a potent inhibitor of the early stage of vaccinia virus replication. Antiviral Res 88:304-10 (2010).Read more (PubMed: 20951746) »
- Margolis LB et al. K+/H+-antiporter nigericin arrests DNA synthesis in Ehrlich ascites carcinoma cells. Proc Natl Acad Sci U S A 86:6626-9 (1989).Read more (PubMed: 2771947) »
See all 3 publications for this product
Publishing research using ab120494? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"