Anti-Nkx3.1 antibody [4H4] (ab96482)

Overview

• Product nameAnti-Nkx3.1 antibody [4H4]See all Nkx3.1 primary antibodies ...
• Description
  Mouse monoclonal [4H4] to Nkx3.1
• Tested applicationsWB, ELISA, IHC-P, Flow Cyt more details
• Species reactivity
  Reacts with: Human
  
• Immunogen

  Recombinant fragment, corresponding to amino acids 1-234 of Human Nkx3.1

• Positive controlLNCaP cell lysate. Human prostate tissue. PC-3 cells.

Properties

• FormLiquid
• Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
• Storage bufferPreservative: 0.03% Sodium Azide
  Constituents: Ascites
• Concentration information loading...
• PurityAscites
• Clonality Monoclonal
• Clone number4H4
• IsotypeIgG2b
• Research Areas
  • Epigenetics and Nuclear Signaling
  • Transcription
  • Transcription Factors

  • Epigenetics and Nuclear Signaling
  • Transcription
  • Domain Families
  • Developmental Families
  • Other

  • Epigenetics and Nuclear Signaling
  • Transcription
  • Other factors

Applications

Target

• FunctionTranscription factor, which binds preferentially the consensus sequence 5'-TAAGT[AG]-3' and can behave as a transcriptional repressor. Play an important role in normal prostate development, regulating proliferation of glandular epithelium and in the formation of ducts in prostate. Act as a tumor suppressor controlling prostate carcinogenesis, as shown by the ability to inhibit proliferation and invasion activities of PC-3 prostate cancer cells.
• Tissue specificityHighly expressed in the prostate and, at a lower level, in the testis.
• Sequence similaritiesBelongs to the NK-3 homeobox family.
  Contains 1 homeobox DNA-binding domain.
• Post-translational
  modificationsUbiquitinated by TOPORS; monoubiquitinated at several residues and also polyubiquitinated on single residues.
• Cellular localizationNucleus.

Target information above from: UniProt accession Q99801 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010) .

Information by UniProt
• Database links
  • Entrez Gene: 4824 Human
  • Omim: 602041 Human
  • SwissProt: Q99801 Human
  • Unigene: 55999 Human

• Alternative names
  BAPX 2 antibodyBAPX2 antibodyHomeobox protein NK-3 homolog A antibody

  Homeobox protein Nkx 3.1 antibodyHomeobox protein Nkx-3.1 antibodyHomeobox protein Nkx3.1 antibodyNK homeobox (Drosophila) family 3 A antibodyNK homeobox family 3 A antibodyNK3 homeobox 1 antibodyNK3 transcription factor homolog A antibodyNK3 transcription factor related locus 1 antibodyNKX 3 antibodyNkx 3.1 antibodyNKX 3A antibodyNKX3 1 antibodyNKX3 antibodyNkx3-1 antibodyNKX3.1 antibodyNKX31_HUMAN antibodyNKX3A antibody

  see all

Anti-Nkx3.1 antibody [4H4] images

• 

  Western blot - Nkx3.1 antibody [4H4] (ab96482)
  Anti-Nkx3.1 antibody [4H4] (ab96482) at 1/500 dilution + LNCaP cell lysate
  
  Predicted band size : 26 kDa
  
• 

  Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Nkx3.1 antibody [4H4] (ab96482)
  Immunohistochemical analysis of paraffin-embedded Human prostate tissues (A, B) using ab96482 at 1/200 dilution with DAB staining.
• 

  Flow Cytometry - Nkx3.1 antibody [4H4] (ab96482)
  Flow cytometry analysis of PC-3 cells using ab96482 at 1/200 dilution (green) and negative control (purple).