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Products:Neuroscience >> Neurotransmitter >> Biogenic Amines >> Noradrenaline
Overview
Product name
Anti-Noradrenaline antibody
See all Noradrenaline products (2) ...
Description
Rabbit polyclonal to Noradrenaline
Specificity
Using a conjugate Noradrenaline-Glutaraldehyde-Protein, antibody specificity was performed with an ELISA test by competition experiments with the following compounds: (Compound = Cross-Reactivity Ratio §) Noradrenaline-G-BSA = 1 Octopamine-G-BSA = 1/31 Dopamine-G-BSA = 1/70 Adrenaline-G-BSA = 1/177 Noradrenaline=G=BSA¥ = 1/316 L-DOPA-G-BSA = 1/>5,000 Tyramine-G-BSA = 1/>5,000 Noradrenaline = 1/>5,000 G = Glutaraldehyde BSA = Bovine Serum Albumin § = Noradrenaline-G-BSA concentration/unconjugated or conjugated catecholamine concentration at half displacement. ¥ = Non-reduced conjugate
Tested applications
ICC, IHC-Fr, IHC-P, ELISAmore details
Immunogen
Chemical / Small Molecule by a Glutaraldehyde linker.
Properties
Form
Liquid
Storage instructions
Store at +4°C.
Storage buffer
Preservative: None
Constituents: 50% Glycerol, ddH20
Concentration
Concentration information loading...
Purity
IgG fraction
Clonality
Polyclonal
Isotype
IgG
Research areas
Signal Transduction >> Growth Factors/Hormones >> Adrenalin
Neuroscience >> Neurotransmitter >> Biogenic Amines >> Noradrenaline
Applications
Show applications key
Our Abpromise guarantee covers the use of ab8887 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
ICC
IHC-Fr
IHC-P
ELISA
Application notes
ELISA: Use at an assay dependent concentration.
ICC: Use at an assay dependent concentration.
IHC-P: Use at an assay dependent dilution (PMID 18457899).
IHC-Fr: Use at an assay dependent concentration.
The recommended dilution can be between 1:2,000-1:5,000.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
Target
Relevance
Noradrenaline (NA) is a catecholamine neurotransmitter at postganglionic sympathetic fibres, produced following a series of steps from the essential amino acid phenylalanine. Terminal postganglionic sympathetic fibres have varicosities (where NA is synthesised and stored) which form synapses with the effector organ. The adrenal medulla is a major source of catecholamines (such as NA and adrenaline), however, most of the NA produced in the adrenal medulla is converted into adrenaline. NA is key in the fight-or-flight response and also directly increases heart rate, energy release from fat, and muscle readiness.
Cellular localization
Secreted
Alternative names
- arterenol antibody
- NA antibody
- Norepinephrine antibody
References for Anti-Noradrenaline antibody (ab8887)
This product has been referenced in:
- Kondo Yet al. Expression and Role of the BDNF Receptor-TrkB in Rat Adrenal Gland under Acute Immobilization Stress. Acta Histochem Cytochem 43:139-47 (2010). ICC/IF.Read more (PubMed: 21245980) »
- Johnson KBet al. Modification of proteins by norepinephrine is important for vascular contraction. Front Physiol 1:131 (2010). WB, ICC/IF, IHC-P.Read more (PubMed: 21423373) »
See all 4 publications for this product
Publishing research using ab8887? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"