Overview
Product nameNoradrenaline transporter peptide
Protein descriptionSynthetic peptide derived from within residues 550 to the C-terminus of Human Noradrenaline transporter.(Note: the amino acid sequence is proprietary)This peptide was used as an immunogen for ab78190 - Noradrenaline transporter antibody.
Protein length617 amino acids
Properties
Purity70 - 90% by HPLC
FormLiquid
Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Storage bufferInformation available upon request.
Concentration information loading...
Research Areas
Applications
Application notesThis peptide can be used with studies using ab78190.
Protein info
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Alternative names
Neurotransmitter transporterNorepinephrine transporterSLC6A2SLC6A5Sodium dependent noradrenaline transporterSolute carrier family 6 (neurotransmitter transporter norepinephrine) member 5Solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2Solute carrier family 6 member 2Solute carrier family 6 member 5
see all
RelevanceCatecholamine, a term used for the hormone adrenaline and its sequentially hydroxylated form noradrenaline, is involved in fight or flight responses. Noradrenaline is released from the post ganglionic sympathetic nerve endings and exerts its effects locally in the immediate vicinity of its release. In the CNS, noradrenaline is involved in a number of physiological responses including mood, sleep regulation, alertness and arousal, both cognitive and non-cognitive expression of behaviors, and control of the endocrine and autonomic nervous systems. Peripherally, noradrenaline is present in sympathetic nerve endings and has full control of the sympathetic nervous system. Noradrenaline released from pre-synaptic nerve terminals is reabsorbed (70-90%) by noradrenaline transporters and its biological effects are terminated. The noradrenaline transport via noradrenaline transporters is an active, Na+/Cl- dependent transport process mediated by noradrenaline transporters. Noradrenaline transporters constitute the primary mechanism for inactivation of synaptically released noradrenaline, are targets for multiple antidepressants and psychostimulants, and are deficient in affective and autonomic disorders. In rat brain, noradrenaline transporter is expressed in noradrenergic neuronal somata, axons and dendrites, and hippocampus and cortex, but is absent from epinephrine- and dopamine-containing neurons.
At least 13 genetic variations have been reported in the noradrenaline transporter protein that affect noradrenaline re-uptake and concentrations in cerebrospinal fluid in humans. The association between these genetic variations in noradrenaline transporters and several psychiatric and cardiovascular disorders is just emerging. Recently, a single amino acid mutation (hNET-A457P) showed deficiency in noradrenaline transport in an orthostatic intolerance patient. Noradrenaline transporter protein consists of 617 amino acids and has 12 trans-membrane domains, a characteristic feature of many membrane associated solute transporters.
Cellular localizationCell Membrane; multi-pass membrane protein
References for Noradrenaline transporter peptide (ab87371)
ab87371
has not yet been referenced specifically in any publications.
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"
