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Anti-Nurr1 antibody [N1404] (ab41917)

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Overview

Product name

Anti-Nurr1 antibody [N1404]
See all Nurr1 products (10) ...

Description

Mouse monoclonal [N1404] to Nurr1

Specificity

Antibody does not recognize alpha and gamma forms.

Tested applications

WB, ELISA, IP, IHC-Pmore details

Cross reactivity

Reacts with

Rat, Human

Immunogen

Recombinant fragment: CVQAQYGSSP QGASPASQSY SYHSSGEYSS DFLTPEFVKF SMDLTNTEIT ATTSLPSFST FMDNYSTGYD VKPPCLYQMP LSGQQSSIKV EDIQMHN, corresponding to amino acids 2-99 of Human Nurr1

CVQAQYGSSP QGASPASQSY SYHSSGEYSS DFLTPEFVKF SMDLTNTEIT ATTSLPSFST FMDNYSTGYD VKPPCLYQMP LSGQQSSIKV EDIQMHN

Run BLAST with BLAST the sequence with ExPASyRun BLAST with BLAST the sequence with NCBI

Positive control

Rat cerebral nerve cell.

Properties

Form

Liquid

Storage instructions

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze / thaw cycles.

Storage buffer

Physiological saline with 0.1% NaN3 as a preservative.

Concentration

Concentration information loading...

Purification notes

Purified from ascites via ammonium sulfate fractionation.

Clonality

Monoclonal

Clone number

N1404

Isotype

IgG2a

Research areas

Cancer >> Cancer Metabolism >> Response to hypoxia
Epigenetics and Nuclear Signaling >> Transcription >> Other factors
Neuroscience >> Neurology process >> Neurogenesis
Immunology >> Immune System Diseases >> Autoimmune
Neuroscience >> Neurology process >> Neural Signal Transduction
Neuroscience >> Neurology process >> Neurodegenerative disease >> Parkinson's disease >> Other

  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Nurr1 antibody [N1404] (ab41917)Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Nurr1 antibody [N1404] (ab41917) image (enlarge)

Applications

Show applications key

Our Abpromise guarantee covers the use of ab41917 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Target

Function

Transcriptional regulator which is important for the differentiation and maintenance of meso-diencephalic dopaminergic (mdDA) neurons during development. It is crucial for expression of a set of genes such as SLC6A3, SLC18A2, TH and DRD2 which are essential for development of mdDA neurons.

Tissue specificity

Expressed in a number of cell lines of T-cell, B-cell and fibroblast origin. Strong expression in brain tissue.

Sequence similarities

Belongs to the nuclear hormone receptor family. NR4 subfamily.
Contains 1 nuclear receptor DNA-binding domain.

Developmental stage

Rapidly and only very transiently expressed after cell activation, during the G0-G1 transition of the cell cycle.

Cellular localization

Nucleus.

Target information above from: UniProt accessionP43354 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).

Information by UniProt

Alternative names

  • HZF 3 antibody
  • HZF3 antibody
  • Immediate-early response protein NOT antibody
  • Intermediate early receptor protein antibody
  • NGFI B/nur77 beta type transcription factor homolog antibody
  • NOT antibody
  • NR4A2 antibody
  • NR4A2_HUMAN antibody
  • Nuclear receptor subfamily 4 group A member 2 antibody
  • Nur related protein 1 homolog antibody
  • Nurr 1 antibody
  • Orphan nuclear receptor NR4A2 antibody
  • Orphan nuclear receptor NURR1 antibody
  • RNR 1 antibody
  • RNR1 antibody
  • T cell nuclear receptor NOT antibody
  • TINUR antibody
  • Transcriptionally inducible nuclear receptor antibody
  • Transcriptionally inducible nuclear receptor related 1 antibody
  • Transcriptionally inducible nuclear receptor related antibody
  • Transcriptionally-inducible nuclear receptor antibody
see all

Database links

Anti-Nurr1 antibody [N1404] images:

  Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Nurr1 antibody [N1404] (ab41917)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Nurr1 antibody [N1404] (ab41917)

ab41917 staining Nurr1 rat cerebral nerve cell paraffin section (10 ug/mL) by immunohistochemistry, formalin-fixed paraffin embedded sections.

References for Anti-Nurr1 antibody [N1404] (ab41917)

ab41917 has not yet been referenced specifically in any publications.

Publishing research using ab41917? Please let us know so that we can cite the reference in this datasheet

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"