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Products:Neuroscience >> Neurology process >> Neurodegenerative disease >> Parkinson's disease >> Other
Overview
Product name
Anti-Nurr1 antibody
See all Nurr1 products (10) ...
Description
Rabbit polyclonal to Nurr1
Tested applications
ELISA, WB, IHC-Pmore details
Cross reactivity
Reacts with
Human
Immunogen
A KLH-conjugated synthetic peptide in the N-terminal region of human Nurr1
Positive control
Mouse brain tissue lysate; human breast carcinoma tissue.
Properties
Form
Liquid
Storage instructions
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze / thaw cycles.
Storage buffer
Preservative: 0.09% Sodium Azide
Constituents: PBS
Concentration
Concentration information loading...
Purity
Ammonium Sulphate Precipitation
Purification notes
This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Clonality
Polyclonal
Isotype
IgG
Research areas
Cancer >> Cancer Metabolism >> Response to hypoxia
Epigenetics and Nuclear Signaling >> Transcription >> Other factors
Neuroscience >> Neurology process >> Neurogenesis
Immunology >> Immune System Diseases >> Autoimmune
Neuroscience >> Neurology process >> Neural Signal Transduction
Neuroscience >> Neurology process >> Neurodegenerative disease >> Parkinson's disease >> Other
Applications
Show applications key
Our Abpromise guarantee covers the use of ab60149 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
ELISA
ELISA: 1/1000ELISA: 1/1000
WB: 1/100 - 1/500.Detects a band of approximately 66 kDa (predicted molecular weight: 66 kDa).
IHC-P: 1/50 - 1/100.
Target
Function
Transcriptional regulator which is important for the differentiation and maintenance of meso-diencephalic dopaminergic (mdDA) neurons during development. It is crucial for expression of a set of genes such as SLC6A3, SLC18A2, TH and DRD2 which are essential for development of mdDA neurons.
Tissue specificity
Expressed in a number of cell lines of T-cell, B-cell and fibroblast origin. Strong expression in brain tissue.
Sequence similarities
Belongs to the nuclear hormone receptor family. NR4 subfamily.
Contains 1 nuclear receptor DNA-binding domain.
Developmental stage
Rapidly and only very transiently expressed after cell activation, during the G0-G1 transition of the cell cycle.
Cellular localization
Nucleus.
Target information above from: UniProt accessionP43354
The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).
Alternative names
- HZF 3 antibody
- HZF3 antibody
- Immediate-early response protein NOT antibody
see all
Database links
- Entrez Gene: 4929 Human
- Omim: 601828 Human
- SwissProt: P43354 Human
- Unigene: 563344 Human
Anti-Nurr1 antibody images:
Western blot - Nurr1 antibody (ab60149)
Anti-Nurr1 antibody (ab60149) at 1/100 dilution + mouse brain tissue lysate
Predicted band size : 66 kDa
Observed band size : 70 kDa (why is the actual band size different from the predicted?)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Nurr1 antibody (ab60149)
Formalin-fixed and paraffin-embedded human brain tissue reacted with NURR1 antibody (N-term) (ab60149), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining.
References for Anti-Nurr1 antibody (ab60149)
ab60149 has not yet been referenced specifically in any publications.
Publishing research using ab60149? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"