Anti-OAS3 antibody (ab154270)
Key features and details
- Rabbit polyclonal to OAS3
- Suitable for: WB, IHC-P
- Reacts with: Human
- Isotype: IgG
Overview
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Product name
Anti-OAS3 antibody
See all OAS3 primary antibodies -
Description
Rabbit polyclonal to OAS3 -
Host species
Rabbit -
Tested applications
Suitable for: WB, IHC-Pmore details -
Species reactivity
Reacts with: Human -
Immunogen
Recombinant fragment, corresponding to a region within amino acids 87-393 of Human OAS3 (Uniprot ID: Q9Y6K5).
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Positive control
- A431 whole cell lysates; Human D54MG xenograft tissue.
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General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle. -
Storage buffer
pH: 7.00
Preservative: 0.025% Proclin 300
Constituents: 78% PBS, 1% BSA, 20% Glycerol (glycerin, glycerine) -
Concentration information loading...
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Purity
Immunogen affinity purified -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
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Positive Controls
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab154270 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
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WB |
1/500 - 1/3000. Predicted molecular weight: 121 kDa.
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IHC-P |
1/100 - 1/1000.
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Notes |
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WB
1/500 - 1/3000. Predicted molecular weight: 121 kDa. |
IHC-P
1/100 - 1/1000. |
Target
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Function
May play a role in mediating resistance to virus infection, control of cell growth, differentiation, and apoptosis. OAS3 synthesizes preferentially dimeric 2',5'-oligoadenylate molecules. GTP can be an alternative substrate. -
Tissue specificity
Present at high level in placenta trophoblast. -
Sequence similarities
Belongs to the 2-5A synthase family. - Information by UniProt
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Database links
- Entrez Gene: 4940 Human
- Omim: 603351 Human
- SwissProt: Q9Y6K5 Human
- Unigene: 528634 Human
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Alternative names
- (2-5'')oligo(A) synthase 3 antibody
- 2 5' oligo(A) synthetase 3 antibody
- 2 5'LIGO antibody
see all
Images
Protocols
Datasheets and documents
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SDS download
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Datasheet download
References (5)
ab154270 has been referenced in 5 publications.
- Domfeh SA et al. The Pharmacologically Active Alkaloid Cryptolepine Activates a Type 1 Interferon Response That Is Independent of MAVS and STING Pathways. J Immunol Res 2022:8873536 (2022). PubMed: 35928633
- Bayne RS et al. MAP3K7 and CHD1 Are Novel Mediators of Resistance to Oncolytic Vesicular Stomatitis Virus in Prostate Cancer Cells. Mol Ther Oncolytics 17:496-507 (2020). PubMed: 32529027
- Nogimori T et al. Dom34 mediates targeting of exogenous RNA in the antiviral OAS/RNase L pathway. Nucleic Acids Res 47:432-449 (2019). PubMed: 30395302
- Nogimori T et al. A novel method for stabilizing microRNA mimics. Biochem Biophys Res Commun 511:422-426 (2019). PubMed: 30799083
- Odon V et al. The role of ZAP and OAS3/RNAseL pathways in the attenuation of an RNA virus with elevated frequencies of CpG and UpA dinucleotides. Nucleic Acids Res 47:8061-8083 (2019). PubMed: 31276592