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Products:Immunology >> Innate Immunity >> Cytokines >> Interferons
Overview
Product name
Anti-OASL antibody
See all OASL products (2) ...
Description
Rabbit polyclonal to OASL
Tested applications
Cross reactivity
Reacts with
Human
Predicted to work with
Mouse, Rat, Cow, Pig
Immunogen
Synthetic peptide corresponding to a region within the N terminal amino acids 35-84 (AVRTVEEFLRQEHFQGKRGLDQDVRVLKVVKVGSFGNGT VLRSTREVELV) of Human OASL, NP_937856
Positive control
Fetal brain lysate (Human)
Properties
Form
Lyophilised:
Add 50 µl of distilled water. Final antibody concentration is 1 mg/ml.
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Storage buffer
Preservative: None
Constituents: 2% Sucrose, PBS
Concentration
Concentration information loading...
Purity
Immunogen affinity purified
Clonality
Polyclonal
Isotype
IgG
Research areas
Cell Biology >> Other Antibodies >> Other Antibodies
Immunology >> Innate Immunity >> Cytokines >> Interferons
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Western blot - OASL antibody (ab86124)
(enlarge)
Applications
Show applications key
Our Abpromise guarantee covers the use of ab86124 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
WB: Use a concentration of 1 µg/mlPredicted molecular weight: 59 kDa.
Target
Relevance
2-prime,5-prime oligoadenylates (2-5As) bind to and activate RNase L, leading to degradation of RNA and inhibition of protein synthesis. 2-5As are produced by 2-5A synthetases (OASs), a highly-conserved family of interferon-induced enzymes. The predicted 514-amino acid human p59OASL (2-5A synthetases-like) protein shares a highly conserved N-terminal domain with other OASs. The C-terminal portion of p59OASL contains 2 ubiquitin-like domains. p59OASL is expressed in most tissues, with the highest levels in hematopoietic tissues, colon, and stomach.
Cellular localization
Cytoplasmic and Nuclear
Alternative names
- p59 OASL antibody
- 2' 5' oligoadenylate synthetase like antibody
- 2'-5' oligoadenylate synthetase-like 2 antibody
see all
Database links
- Entrez Gene: 408021 Cow
- Entrez Gene: 8638 Human
- Entrez Gene: 23962 Mouse
- Entrez Gene: 595119 Pig
- Omim: 603281 Human
- SwissProt: Q6WRU5 Cow
- SwissProt: Q15646 Human
- SwissProt: Q17R95 Human
see all
Anti-OASL antibody images:
Western blot - OASL antibody (ab86124)
Anti-OASL antibody (ab86124) at 1 µg/ml + Fetal brain lysate (Human) at 10 µg
Secondary
HRP conjugated anti-Rabbit IgG at 1/50000 dilution
Predicted band size : 59 kDa
Additional bands at : 27 kDa. We are unsure as to the identity of these extra bands.
Gel concentration: 12%
References for Anti-OASL antibody (ab86124)
ab86124 has not yet been referenced specifically in any publications.
Publishing research using ab86124? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"