Anti-OB Cadherin antibody [16G5] (ab151446)
Key features and details
- Mouse monoclonal [16G5] to OB Cadherin
- Suitable for: WB
- Reacts with: Human
- Isotype: IgG1
Overview
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Product name
Anti-OB Cadherin antibody [16G5]
See all OB Cadherin primary antibodies -
Description
Mouse monoclonal [16G5] to OB Cadherin -
Host species
Mouse -
Tested applications
Suitable for: WBmore details -
Species reactivity
Reacts with: Human -
Immunogen
Extracellular Cadherin domain 1 of OB Cadherin fused to maltose binding protein (P55287).
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General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles. -
Storage buffer
Preservative: 0.1% Sodium azide
Constituent: 99% PBS -
Concentration information loading...
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Purity
Protein A purified -
Clonality
Monoclonal -
Clone number
16G5 -
Myeloma
NS1 -
Isotype
IgG1 -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
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Recombinant Protein
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab151446 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
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WB |
1/100. Predicted molecular weight: 87 kDa.
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Notes |
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WB
1/100. Predicted molecular weight: 87 kDa. |
Target
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Function
Cadherins are calcium dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. -
Tissue specificity
Expressed mainly in brain but also found in other tissues. Expressed in neuroblasts. -
Involvement in disease
Note=A chromosomal aberration involving CDH11 is a common genetic feature of aneurysmal bone cyst, a benign osseous neoplasm. Translocation t(16;17)(q22;p13) with USP6. The translocation generates a fusion gene in which the strong CDH11 promoter is fused to the entire USP6 coding sequence, resulting in USP6 transcriptional up-regulation. -
Sequence similarities
Contains 5 cadherin domains. -
Cellular localization
Cell membrane. - Information by UniProt
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Database links
- Entrez Gene: 1009 Human
- Omim: 600023 Human
- SwissProt: P55287 Human
- Unigene: 116471 Human
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Alternative names
- CAD11 antibody
- CAD11_HUMAN antibody
- Cadherin 11 antibody
see all
Images
Datasheets and documents
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SDS download
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Datasheet download
References (3)
ab151446 has been referenced in 3 publications.
- Koike T et al. Altered sulfation status of FAM20C-dependent chondroitin sulfate is associated with osteosclerotic bone dysplasia. Nat Commun 13:7952 (2022). PubMed: 36572689
- Ma C et al. Combined overexpression of cadherin 6, cadherin 11 and cluster of differentiation 44 is associated with lymph node metastasis and poor prognosis in oral squamous cell carcinoma. Oncol Lett 15:9498-9506 (2018). PubMed: 29805672
- Kim C et al. Universal antibody conjugation to nanoparticles using the Fc? receptor I (Fc?RI): quantitative profiling of membrane biomarkers. Bioconjug Chem 25:1893-901 (2014). PubMed: 25215471