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Products:Epigenetics and Nuclear Signaling >> DNA / RNA >> DNA Damage & Repair >> DNA Damage Response >> DNA Damage Recognition
Overview
Product name
Anti-OBFC2B antibody
See all OBFC2B products (3) ...
Description
Rabbit polyclonal to OBFC2B
Tested applications
IHC-Pmore details
Cross reactivity
Reacts with
Mouse, Human
Immunogen
Synthetic peptide corresponding to a region within amino acids 161 - 211 of Human OBFC2B (NP_076973.1)
Positive control
Human breast or colon carcinoma. Mouse squamous cell carcinoma.
Properties
Form
Liquid
Storage instructions
Store at +4°C.
Storage buffer
Preservative: 0.09% Sodium Azide
Constituents: 0.1% BSA, Tris buffered saline
Concentration
Concentration information loading...
Purity
Immunogen affinity purified
Clonality
Polyclonal
Isotype
IgG
Research areas
Epigenetics and Nuclear Signaling >> Chromatin Binding Proteins >> DNA / RNA binding
Epigenetics and Nuclear Signaling >> DNA / RNA >> DNA Damage & Repair >> DNA Damage Response >> Other
Epigenetics and Nuclear Signaling >> DNA / RNA >> DNA Damage & Repair >> DNA Damage Response >> DNA Damage Recognition
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - OBFC2B antibody (ab87265)
(enlarge)
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - OBFC2B antibody (ab87265)
(enlarge)
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - OBFC2B antibody (ab87265)
(enlarge)
Applications
Show applications key
Our Abpromise guarantee covers the use of ab87265 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
IHC-P: 1/100 - 1/500.
Target
Relevance
Single-stranded DNA (ssDNA)-binding proteins, such as OBFC2B, are ubiquitous and essential for a variety of DNA metabolic processes, including replication, recombination, and detection and repair of damage. OBFC2B plays an important role in DNA damage response. It influences diverse endpoints in the cellular DNA damage response, including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. It associates with DNA lesions, and enables the efficient activation of ATM and consequent phosphorylation of downstream proteins.
Cellular localization
Nuclear. Localizes to nuclear foci following DNA damage.
Alternative names
- MGC2731 antibody
- Nabp2 antibody
- SOSS complex subunit B1 antibody
see all
Database links
- Entrez Gene: 79035 Human
- Entrez Gene: 69917 Mouse
- Omim: 612104 Human
- SwissProt: Q9BQ15 Human
- SwissProt: Q8R2Y9 Mouse
Anti-OBFC2B antibody images:
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - OBFC2B antibody (ab87265)
ab87265 at a 1/500 dilution staining OBFC2B in Human colon carcinoma tissue. DAB staining.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - OBFC2B antibody (ab87265)
ab87265 at a 1/500 dilution staining OBFC2B in Human colon carcinoma tissue. DAB staining.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - OBFC2B antibody (ab87265)
ab87265 at a 1/100 dilution staining OBFC2B in Mouse squamous cell carcinoma tissue. DAB staining.
References for Anti-OBFC2B antibody (ab87265)
ab87265 has not yet been referenced specifically in any publications.
Publishing research using ab87265? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"