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Product name
ODQ
Description
Selective, potent inhibitor of NO-sensitive guanylyl cyclase
Biological description
Selective, potent inhibitor of nitric oxide-sensitive guanylyl cyclase.
Purity
> 99%
General notes
Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 6 months.
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Properties
Chemical name
1H-[1,2,4]Oxadiazolo[4,3-a]quinoxalin-1-one
Molecular Weight
187.16
Chemical structure
Molecular formula
C9H5N3O2
CAS Number
41443-28-1
Solubility
Soluble in DMSO to 100 mM and in ethanol to 25 mM
Storage instructions
Store at +4°C (desiccating conditions). Do not freeze.
Research areas
Biochemicals >> Pharmacology >> Enzymes >> Cyclase >> Guanylyl cyclase >> Inhibitors
Biochemicals >> Chemical Type >> Biochemicals
References for ODQ (ab120022)
This product has been referenced in:
- Homer KL et al. Inhibition by 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one (ODQ) of responses to nitric oxide-donors in rat pulmonary artery: influence of the mechanism of nitric oxide generation. J Pharm Pharmacol 51:135-9 (1999).Read more (PubMed: 10217311) »
- Schrammel A et al. Characterization of 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one as a heme-site inhibitor of nitric oxide-sensitive guanylyl cyclase. Mol Pharmacol 50:1-5 (1996).Read more (PubMed: 8700100) »
See all 3 publications for this product
Publishing research using ab120022? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"