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Products:Immunology >> Innate Immunity >> Cytokines >> Interleukins
Overview
Product name
Anti-OSMR antibody
See all OSMR products (2) ...
Description
Mouse polyclonal to OSMR
Specificity
This antibody is reactive against mammalian transfected lysate.
Tested applications
Cross reactivity
Reacts with
Human
Immunogen
Full length OSMR protein (Human)
Positive control
OSMR transfected 293T cell lysate
Properties
Form
Liquid
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Storage buffer
Preservative: None
Constituents: 1X PBS, pH 7.2
Concentration
Concentration information loading...
Purity
Protein A purified
Clonality
Polyclonal
Isotype
IgG
Research areas
Epigenetics and Nuclear Signaling >> Nuclear Signaling Pathways >> STATs
Signal Transduction >> Signaling Pathway >> Nuclear Signaling >> STATs
Immunology >> Innate Immunity >> Cytokines >> IL6 Related
Immunology >> Innate Immunity >> Cytokines >> Interleukins
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Western blot - OSMR antibody (ab67805)
(enlarge)
Applications
Show applications key
Our Abpromise guarantee covers the use of ab67805 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
- 1 Image
WB
Application notes
WB: 1/500 - 1/1000.
Detection Antibody Pair.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
Target
Relevance
Oncostatin M is a member of the IL6 family of cytokines. Functional receptors for IL6 family cytokines are multisubunit complexes involving members of the hematopoietin receptor superfamily. Many IL6 cytokines utilize gp130 as a common receptor subunit. OSM binds to the gp130 receptor subunit and, in association with the leukemia inhibitory factor receptor, induces a proliferative response in permissive cells. OSMR is an alternative subunit (for an OSM receptor complex (a heterodimer of gp130 and OSMR) that is activated by OSM but not by LIF. [Entrez Gene]
Cellular localization
Membrane; Single pass type I membrane protein
Alternative names
- MGC140467 antibody
- MGC150626 antibody
- MGC150627 antibody
see all
Database links
- Entrez Gene: 9180 Human
- Omim: 601743 Human
- SwissProt: Q99650 Human
- Unigene: 120658 Human
Anti-OSMR antibody images:
Western blot - OSMR antibody (ab67805)
All lanes : Anti-OSMR antibody (ab67805) at 1/500 dilution
Lane 1 : OSMR transfected 293T cell lysate
Lane 2 : Non-transfected 293T cell lysate
Lysates/proteins at 25 µg per lane.
Secondary
Goat Anti-Mouse IgG (H&L)-HRP Conjugate at 1/2500 dilution
Observed band size : 50 kDa (why is the actual band size different from the predicted?)
References for Anti-OSMR antibody (ab67805)
This product has been referenced in:
- Larrea Eet al. Oncostatin M enhances the antiviral effects of type I interferon and activates immunostimulatory functions in liver epithelial cells. J Virol 83:3298-311 (2009). WB; Human.Read more (PubMed: 19158240) »
See 1 publication for this product
Publishing research using ab67805? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"