Anti-OXCT1 antibody (ab104021)

Overview

• Product nameAnti-OXCT1 antibodySee all OXCT1 primary antibodies ...
• Description
  Rabbit polyclonal to OXCT1
• Tested applicationsWB, IHC-P more details
• Species reactivity
  Reacts with: Human
  
• Immunogen

  KLH conjugated synthetic peptide corresponding to a region within internal amino acids 282-312 from Human OXCT1 (UniProt P55809).

• Positive controlJurkat cell line lysates; Human brain tissue

Properties

• FormLiquid
• Storage instructionsStore at 4°C (up to 6 months). For long term storage store at -20°C
• Storage bufferPreservative: 0.09% Sodium Azide
  Constituents: PBS
• Concentration information loading...
• PurityImmunogen affinity purified
• Purification notesab104021 is purified through a protein A column, followed by peptide affinity purification.
• Clonality Polyclonal
• IsotypeIgG
• Research Areas
  • Metabolism
  • Types of disease
  • Cancer

  • Metabolism
  • Pathways and Processes
  • Metabolic signaling pathways
  • Lipid and lipoprotein metabolism
  • Lipid metabolism

  • Metabolism
  • Pathways and Processes
  • Mitochondrial Metabolism
  • Mitochondrial markers

  • Metabolism
  • Pathways and Processes
  • Metabolic signaling pathways
  • Energy transfer pathways
  • Energy Metabolism

  • Cancer
  • Cancer Metabolism
  • Metabolic signaling pathway
  • Metabolism of lipids and lipoproteins

  • Signal Transduction
  • Metabolism
  • Energy Metabolism

  • Signal Transduction
  • Metabolism
  • Mitochondrial

Applications

Target

• FunctionKey enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate.
• Tissue specificityAbundant in heart, followed in order by kidney, brain, and muscle, whereas in liver it is undetectable; also detectable in leukocytes and fibroblasts.
• PathwayKetone metabolism; succinyl-CoA degradation; acetoacetyl-CoA from succinyl-CoA: step 1/1.
• Involvement in diseaseDefects in OXCT1 are a cause of SCOT deficiency (SCOTD) [MIM:245050].
• Sequence similaritiesBelongs to the 3-oxoacid CoA-transferase family.
• Cellular localizationMitochondrion matrix.

Target information above from: UniProt accession P55809 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010) .

Information by UniProt
• Database links
  • Entrez Gene: 5019 Human
  • Omim: 601424 Human
  • SwissProt: P55809 Human
  • Unigene: 278277 Human

• Alternative names
  3 oxoacid CoA transferase 1 antibody3-oxoacid-CoA transferase 1 antibodyEC 2.8.3.5 antibody

  OTTHUMP00000120012 antibodyOTTHUMP00000221550 antibodyOXCT antibodyOXCT1 antibodySCOT antibodyScot S antibodyScot-S antibodySCOT1_HUMAN antibodySomatic type succinyl CoA:3 oxoacid CoA transferase antibodySomatic-type succinyl-CoA:3-oxoacid-CoA-transferase antibodySuccinyl CoA:3 ketoacid CoA transferase antibodySuccinyl CoA:3 ketoacid coenzyme A transferase 1 mitochondrial antibodySuccinyl CoA:3 oxoacid CoA transferase antibodySuccinyl-CoA:3-ketoacid-coenzyme A transferase 1, mitochondrial antibody

  see all

Anti-OXCT1 antibody images

• 

  Western blot - OXCT1 antibody (ab104021)
  Anti-OXCT1 antibody (ab104021) at 1/100 dilution + Jurkat cell line lysates at 35 µg
  
  Predicted band size : 56 kDa
  
• 

  Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - OXCT1 antibody (ab104021)
  ab104021, at a 1/50 dilution, staining OXCT1 in formalin fixed and paraffin embedded Human brain tissue by Immunohistochemistry, followed by peroxidase conjugation to the secondary antibody and DAB staining.