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Overview

  • Product nameAnti-OXCT1 antibodySee all OXCT1 primary antibodies ...
  • Description
    Rabbit polyclonal to OXCT1
  • Tested applicationsWB, ELISA, IHC-P more details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat
  • Immunogen

    Recombinant fragment, corresponding to amino acids 171-434 of Human OXCT1 (BC009001).

  • Positive controlHuman fetal heart and brain lysates; Human fetal kidney tissue.

Properties

Applications

Our Abpromise guarantee covers the use of ab105320 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Notes
WB WB: 1/500 - 1/1000. Predicted molecular weight: 56 kDa.
ELISA ELISA: 1/20000 - 1/80000.
IHC-P IHC-P: 1/100 - 1/500.

Target

  • FunctionKey enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate.
  • Tissue specificityAbundant in heart, followed in order by kidney, brain, and muscle, whereas in liver it is undetectable; also detectable in leukocytes and fibroblasts.
  • PathwayKetone metabolism; succinyl-CoA degradation; acetoacetyl-CoA from succinyl-CoA: step 1/1.
  • Involvement in diseaseDefects in OXCT1 are a cause of SCOT deficiency (SCOTD) [MIM:245050].
  • Sequence similaritiesBelongs to the 3-oxoacid CoA-transferase family.
  • Cellular localizationMitochondrion matrix.

    • Target information above from: UniProt accession P55809 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt
  • Database links
    see all
  • Alternative names
      3 oxoacid CoA transferase 1 antibody3-oxoacid-CoA transferase 1 antibodyEC 2.8.3.5 antibody
      mitochondrial antibodyOTTHUMP00000120012 antibodyOTTHUMP00000221550 antibodyOXCT antibodyOxct1 antibodySCOT antibodyScot S antibodyScot-S antibodySCOT1_HUMAN antibodySomatic type succinyl CoA:3 oxoacid CoA transferase antibodySomatic-type succinyl-CoA:3-oxoacid-CoA-transferase antibodySuccinyl CoA:3 ketoacid CoA transferase antibodySuccinyl CoA:3 ketoacid coenzyme A transferase 1 mitochondrial antibodySuccinyl CoA:3 oxoacid CoA transferase antibodySuccinyl-CoA:3-ketoacid-coenzyme A transferase 1 antibodySuccinyl-CoA:3-ketoacid-coenzyme A transferase 1, mitochondrial antibody
    see all

Anti-OXCT1 antibody images

  • Western blot - OXCT1 antibody (ab105320)
    Western blot - OXCT1 antibody (ab105320)
    All lanes : Anti-OXCT1 antibody (ab105320) at 1/500 dilution

    Lane 1 : Human fetal heart lysate
    Lane 2 : Human fetal brain lysate


    Predicted band size : 56 kDa
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - OXCT1 antibody (ab105320)
    Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - OXCT1 antibody (ab105320)
    ab105320 at 1/100 dilution staining OXCT1 in Human fetal kidney tissue

References for Anti-OXCT1 antibody (ab105320)

ab105320 has not yet been referenced specifically in any publications.

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