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Read our guarantee »Overview
Product name
OcTMAB™
Description
Cell permeable dynamin I and dynamin II inhibitor
Biological description
Cell permeable dynamin I and dynamin II inhibitor (IC50 = 1.9 and 4.4 µM for inhibition of dynamin I and II GTPase respectively). Targets the pleckstrin homology (PH) (lipid binding) domain. Competitive with phospholipid and noncompetitive with GTP. Inhibits receptor-mediated endocytosis (IC50 = 6.7 µM). Inhibits cancer cell growth.
Purity
> 98%
General notes
Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 6 months.
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one week. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Sold under exclusive licence from Children's Medical Research Institute and Newcastle Innovation Ltd. OcTMAB™ is a trademark of Children's Medical Research Institute and Newcastle Innovation Ltd.
Properties
Chemical name
Octadecyltrimethylammonium bromide
Molecular Weight
392.51
Chemical structure
Molecular formula
C21H46BrN
CAS Number
1120-02-1
Solubility
Soluble in DMSO to 25 mM (with warming)
Storage instructions
Store at room temperature (desiccating conditions).
Research areas
Biochemicals >> Research Area >> Stroke >> Signaling >> Endocytosis & exocytosis >> Dynamin
Biochemicals >> Research Area >> Respiratory disease >> Signaling >> Endocytosis & exocytosis >> Dynamin
Biochemicals >> Research Area >> Pain & inflammation >> Signaling >> Endocytosis & exocytosis >> Dynamin
Biochemicals >> Research Area >> Obesity >> Signaling >> Endocytosis & exocytosis >> Dynamin
Biochemicals >> Research Area >> Hypertension >> Signaling >> Endocytosis & exocytosis >> Dynamin
Biochemicals >> Research Area >> Heart disease >> Signaling >> Endocytosis & exocytosis >> Dynamin
Biochemicals >> Research Area >> Diabetes >> Signaling >> Endocytosis & exocytosis >> Dynamin
Biochemicals >> Research Area >> Cancer >> Signaling >> Endocytosis & exocytosis >> Dynamin
Biochemicals >> Research Area >> Alzheimer's Disease >> Signaling >> Endocytosis & exocytosis >> Dynamin
Biochemicals >> Pharmacology >> Signaling >> Endocytosis & exocytosis >> Dynamin
Biochemicals >> Pharmacology >> Enzymes >> ATPase & GTPase >> Inhibitors
Biochemicals >> Chemical Type >> Biochemicals
References for OcTMAB™ (ab120467)
This product has been referenced in:
- Joshi S et al. The dynamin inhibitors MiTMAB and OcTMAB induce cytokinesis failure and inhibit cell proliferation in human cancer cells. Mol Cancer Ther 9:1995-2006 (2010).Read more (PubMed: 20571068) »
- Quan A et al. Myristyl trimethyl ammonium bromide and octadecyl trimethyl ammonium bromide are surface-active small molecule dynamin inhibitors that block endocytosis mediated by dynamin I or dynamin II. Mol Pharmacol 72:1425-39 (2007).Read more (PubMed: 17702890) »
See all 2 publications for this product
Publishing research using ab120467? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"