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Anti-Ogg1 antibody (ab62826)

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Overview

Product name

Anti-Ogg1 antibody
See all Ogg1 products (7) ...

Description

Goat polyclonal to Ogg1

Tested applications

WB, ELISAmore details

Cross reactivity

Reacts with

Rat

Predicted to work with

Mouse, Cow, Human

Immunogen

Synthetic peptide: C-HPKTSQAKGPSPLANK, corresponding to internal sequence amino acids 282-297 of Rat Ogg1

C-HPKTSQAK GPSPLANK

Positive control

Rat Spleen lysate

Properties

Form

Liquid

Storage instructions

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

Storage buffer

Preservative: 0.02% Sodium Azide
Constituents: 0.5% BSA, Tris buffered saline, pH 7.3

Concentration

Concentration information loading...

Purity

Immunogen affinity purified

Purification notes

Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.

Clonality

Polyclonal

Isotype

IgG

  • Western blot - Ogg1 antibody (ab62826)Western blot - Ogg1 antibody (ab62826) image (enlarge)

Applications

Show applications key

Our Abpromise guarantee covers the use of ab62826 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Target

Function

DNA repair enzyme that incises DNA at 8-oxoG residues. Excises 7,8-dihydro-8-oxoguanine and 2,6-diamino-4-hydroxy-5-N-methylformamidopyrimidine (FAPY) from damaged DNA. Has a beta-lyase activity that nicks DNA 3' to the lesion.

Tissue specificity

Ubiquitous.

Involvement in disease

Defects in OGG1 may be a cause of renal cell carcinoma (RCC) [MIM:144700]. It is a heterogeneous group of sporadic or hereditary carcinoma derived from cells of the proximal renal tubular epithelium. It is subclassified into clear cell renal carcinoma (non-papillary carcinoma), papillary renal cell carcinoma, chromophobe renal cell carcinoma, collecting duct carcinoma with medullary carcinoma of the kidney, and unclassified renal cell carcinoma.

Sequence similarities

Belongs to the type-1 OGG1 family.

Cellular localization

Mitochondrion; Nucleus and Nucleus > nucleoplasm. Nucleus speckle. Nucleus matrix. Together with APEX1 is recruited to nuclear speckles in UVA-irradiated cells.

Target information above from: UniProt accessionO15527 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).

Information by UniProt

Alternative names

  • 8 hydroxyguanine DNA glycosylase antibody
  • 8 oxoguanine DNA glycosylase 1 antibody
  • 8 oxoguanine DNA glycosylase antibody
  • AP lyase antibody
  • DNA (apurinic or apyrimidinic site) lyase antibody
  • DNA apurinic or apyrimidinic site lyase antibody
  • DNA lyase antibody
  • DNA-(apurinic or apyrimidinic site) lyase antibody
  • HMMH antibody
  • HOGG 1 antibody
  • HOGG1 antibody
  • MMH antibody
  • MUTM antibody
  • N glycosylase antibody
  • Ogg 1 antibody
  • Ogg1 antibody
  • OGG1_HUMAN antibody
  • OGH 1 antibody
  • OGH1 antibody
see all

Anti-Ogg1 antibody images:

  Western blot - Ogg1 antibody (ab62826)

Western blot - Ogg1 antibody (ab62826)

Anti-Ogg1 antibody (ab62826) at 0.1 µg/ml + Rat Spleen lysate at 35 µg

Predicted band size : 39 kDa
Observed band size : 37 kDa (why is the actual band size different from the predicted?)


Detected by chemiluminescence

References for Anti-Ogg1 antibody (ab62826)

ab62826 has not yet been referenced specifically in any publications.

Publishing research using ab62826? Please let us know so that we can cite the reference in this datasheet

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"