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Products:Neuroscience >> Cell Type Marker >> Glia marker >> Oligodendrocyte marker
Overview
Product name
Anti-Oligodendrocyte Specific Protein antibody, prediluted
See all Oligodendrocyte Specific Protein products (5) ...
Description
Rabbit polyclonal to Oligodendrocyte Specific Protein, prediluted
Tested applications
IHC-Pmore details
Cross reactivity
Reacts with
Human
Predicted to work with
Mouse, Rat
Immunogen
A synthetic peptide from the C terminal of Human OSP.
Positive control
Testis and mouse brain.
Properties
Form
Liquid
Storage instructions
Store at +4°C.
Storage buffer
Preservative: 0.1% Sodium Azide
Constituents: 1% BSA, 50mM Tris, pH 7.6
Concentration
Concentration information loading...
Purity
Immunogen affinity purified
Clonality
Polyclonal
Isotype
IgG
Research areas
Neuroscience >> Neurology process >> Neurodegenerative disease >> Other
Immunology >> Immune System Diseases >> Autoimmune
Neuroscience >> Cell Type Marker >> Glia marker >> Oligodendrocyte marker
Applications
Show applications key
Our Abpromise guarantee covers the use of ab27565 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
IHC-P: 1/0Perform heat mediated antigen retrieval before commencing with IHC staining protocol.
Target
Relevance
Oligodendrocyte specific protein (OSP), also known Claudin 11, is the third most abundant component of central nervous system myelin. The claudin superfamily consists of many structurally related proteins. These proteins, which include claudin 1 through 18, are located in both epithelial and endothelial cells in all tight junction bearing tissues. Claudins, which consist of four transmembrane domains and two extracellular loops, make up tight junction strands. There is growing evidence that OSP/Claudin 11 determines the permeability between layers of myelin sheaths via focal adhesion. Its expression is highly regulated during development, suggesting that it may play an important role in the growth and differentiation of oligodendrocytes and other cells outside the CNS. In addition, the protein is a candidate autoantigen in the development of autoimmune demyelinating disease.
Cellular localization
Integral cell membrane protein. Tight junctions.
Alternative names
- Claudin 11 antibody
- claudin11 antibody
- CLDN 11 antibody
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Database links
- Entrez Gene: 5010 Human
- Entrez Gene: 18417 Mouse
- Entrez Gene: 84588 Rat
- Omim: 601326 Human
- SwissProt: O75508 Human
- SwissProt: Q60771 Mouse
- SwissProt: Q99P82 Rat
- Unigene: 31595 Human
see all
References for Anti-Oligodendrocyte Specific Protein antibody, prediluted (ab27565)
This product has been referenced in:
- Fink Cet al. Claudin-11 is over-expressed and dislocated from the blood-testis barrier in Sertoli cells associated with testicular intraepithelial neoplasia in men. Histochem Cell Biol 131:755-64 (2009). IHC-P; Human.Read more (PubMed: 19241088) »
See 1 publication for this product
Publishing research using ab27565? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"