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Anti-Otx2 antibody (ab76748)

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Overview

Product name

Anti-Otx2 antibody
See all Otx2 products (3) ...

Description

Rabbit polyclonal to Otx2

Specificity

Reacts specifically with 31 kDa Otx2 protein.

Tested applications

IHC-P, WBmore details

Cross reactivity

Reacts with

Human

Predicted to work with

Rat

Immunogen

Synthetic peptide derived from the N terminal domain of human Otx2

Properties

Form

Liquid

Storage instructions

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.

Storage buffer

Preservative: None
Constituents: Whole serum

Purity

Whole antiserum

Clonality

Polyclonal

Isotype

IgG

Research areas

Developmental Biology >> Organogenesis >> Nervous system development
Developmental Biology >> Lineage specification >> Ectoderm
Developmental Biology >> Embryogenesis >> Axis formation and symmetry
Stem Cells >> Lineage Markers >> Ectoderm
Epigenetics and Nuclear Signaling >> Transcription >> Other factors
Neuroscience >> Sensory System >> Visual system

Applications

Show applications key

Our Abpromise guarantee covers the use of ab76748 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • IHC-P

     IHC-P: 1/50 - 1/200.

    IHC-P: 1/50 - 1/200.

  • ShowHide

    WB

     WB: 1/100 - 1/1000.Predi...Read more →

    WB: 1/100 - 1/1000.Predicted molecular weight: 32 kDa.

Target

Function

Probably plays a role in the development of the brain and the sense organs. Can bind to the BCD target sequence (BTS): 5'-TCTAATCCC-3'.

Tissue specificity

Expressed in brain.

Involvement in disease

Defects in OTX2 are the cause of microphthalmia syndromic type 5 (MCOPS5) [MIM:610125]. Microphthalmia is a clinically heterogeneous disorder of eye formation, ranging from small size of a single eye to complete bilateral absence of ocular tissues. Up to 80% of cases of microphthalia occur in association with syndromes that include non-ocular abnormalities. MCOPS5 patients manifest unilateral or bilateral microphthalmia/clinical anophthalmia and variable additional features including coloboma, microcornea, cataract, retinal dystrophy, hypoplasia or agenesis of the optic nerve, agenesis of the corpus callosum, developmental delay, joint laxity, hypotonia, and seizures.

Sequence similarities

Belongs to the paired homeobox family. Bicoid subfamily.
Contains 1 homeobox DNA-binding domain.

Developmental stage

Embryo.

Cellular localization

Nucleus.

Target information above from: UniProt accessionP32243 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).

Information by UniProt

Alternative names

  • Homeobox protein OTX2 antibody
  • MCOPS 5 antibody
  • MCOPS5 antibody
  • MGC45000 antibody
  • Orthodenticle 2 antibody
  • Orthodenticle homeobox 2 antibody
  • Orthodenticle homolog 2 (Drosophila) antibody
  • Orthodenticle homolog 2 antibody
  • Orthodenticle2 antibody
  • Otx 2 antibody
  • otx2 antibody
  • OTX2_HUMAN antibody
see all

Database links

References for Anti-Otx2 antibody (ab76748)

ab76748 has not yet been referenced specifically in any publications.

Publishing research using ab76748? Please let us know so that we can cite the reference in this datasheet

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"