Overview

  • Product name
    Ouabain octahydrate
  • Description
    Na+/K+ ATPase inhibitor
  • Biological description
    Na+/K+ ATPase inhibitor (Ki = 30 μM). Cardiac glycoside. Stimulates activity at low nanomolar concentrations in rats. Improves cardiac function in myocardial infarction rats. Centrally active following oral administration.
  • Purity
    > 97%
  • General notes

    It has been reported that an aqueous solution of this material stored overnight in a borosilicate glass vial leads to the formation of ouabain-borate complexes.
    It is therefore recommended that this material is stored in a plastic vial and any contact with borosilicate glass is minimised.

Properties

References

This product has been referenced in:
  • Nelissen-Vrancken HJ  et al. Ouabain improves cardiac function in vivo in rats with heart failure after chronic but not acute treatment. Naunyn Schmiedebergs Arch Pharmacol 356:203-9 (1997). Read more (PubMed: 9272726) »
  • Blaustein MP Endogenous ouabain: role in the pathogenesis of hypertension. Kidney Int 49:1748-53 (1996). Read more (PubMed: 8743490) »
  • Huang BS  et al. Chronic central versus peripheral ouabain, blood pressure, and sympathetic activity in rats. Hypertension 23:1087-90 (1994). Read more (PubMed: 7911450) »
  • Hara Y  et al. Expression of active alpha-3 subunit of rat brain Na+,K+-ATPase from the messenger RNA injected into Xenopus oocytes. Biochem Biophys Res Commun 163:102-5 (1989). Read more (PubMed: 2549984) »

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"

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