Overview

  • Product name
    Oxamflatin
  • Description
    Potent mammalian HDAC inhibitor
  • Biological description
    Potent mammalian HDAC inhibitor (IC50 = 15.7 nM). Induces an elongated cell shape morphology with filamentous protrusions. Shows antiproliferative effects. Shows antitumor effects in vivo.
  • Purity
    > 95%

Properties

  • Chemical name
    (E)-5-[3-(Benzenesulfonamido)phenyl]-N-hydroxypent-2-en-4-ynamide
  • Molecular weight
    342.37
  • Chemical structure
    Chemical Structure
  • Molecular formula
    C17H14N2O4S
  • CAS Number
    934986-71-7
  • PubChem identifier
    5353852
  • Storage instructions
    Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview
    Soluble in DMSO to 25 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES
    C1=CC=C(C=C1)S(=O)(=O)NC2=CC=CC(=C2)C#C/C=C/C(=O)NO
  • Source

    Synthetic

References

This product has been referenced in:
  • Hou L  et al. Effects of histone deacetylase inhibitor oxamflatin on in vitro porcine somatic cell nuclear transfer embryos. Cell Reprogram 16:253-65 (2014). Read more (PubMed: 24960409) »
  • Ghosh SK  et al. Histone deacetylase inhibitors are potent inducers of gene expression in latent EBV and sensitize lymphoma cells to nucleoside antiviral agents. Blood 119:1008-17 (2012). Read more (PubMed: 22160379) »
  • Kim YB  et al. Oxamflatin is a novel antitumor compound that inhibits mammalian histone deacetylase. Oncogene 18:2461-70 (1999). Read more (PubMed: 10229197) »

See 0 Publications for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"

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