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Anti-P Glycoprotein antibody [JSB-1], prediluted (ab51893)

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Overview

  • Product nameAnti-P Glycoprotein antibody [JSB-1], predilutedSee all P Glycoprotein primary antibodies ...
  • Description
    Mouse monoclonal [JSB-1] to P Glycoprotein, prediluted
  • Tested applicationsIHC-P more details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Chinese hamster ovary cell line (CHrC5) expressing Human MDR (170-180 kDa Glykoprotein)

  • Positive controlHuman liver or renal carcinoma.

Properties

Applications

Our Abpromise guarantee covers the use of ab51893 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Notes
IHC-P
  • Application notesIHC-P: we recommend using 100µl working solution per test and incubating the antibody for 60 mins at room temperature. Antigen unmasking required for paraffin embedded sections.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.

    • Target

    • FunctionEnergy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells.
    • Tissue specificityExpressed in liver, kidney, small intestine and brain.
    • Involvement in diseaseGenetic variations in ABCB1 are associated with susceptibility to inflammatory bowel disease type 13 (IBD13) [MIM:612244]. Inflammatory bowel disease is characterized by a chronic relapsing intestinal inflammation. It is subdivided into Crohn disease and ulcerative colitis phenotypes. Crohn disease may involve any part of the gastrointestinal tract, but most frequently the terminal ileum and colon. Bowel inflammation is transmural and discontinuous; it may contain granulomas or be associated with intestinal or perianal fistulas. In contrast, in ulcerative colitis, the inflammation is continuous and limited to rectal and colonic mucosal layers; fistulas and granulomas are not observed. Both diseases include extraintestinal inflammation of the skin, eyes, or joints. Crohn disease and ulcerative colitis are commonly classified as autoimmune diseases.
    • Sequence similaritiesBelongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily.
      Contains 2 ABC transmembrane type-1 domains.
      Contains 2 ABC transporter domains.
    • Cellular localizationMembrane.

      • Target information above from: UniProt accession P08183 The UniProt Consortium
      The Universal Protein Resource (UniProt) in 2010
      Nucleic Acids Res. 38:D142-D148 (2010) .

      Information by UniProt
    • Database links
      • Alternative names
          ABC20 antibodyABCB1 antibodyATP binding cassette sub family B MDR/TAP member 1 antibody
          ATP binding cassette, sub family B (MDR/TAP), member 1 antibodyATP-binding cassette sub-family B member 1 antibodyCD243 antibodyCD243 antigen antibodyCLCS antibodyColchicin sensitivity antibodyDoxorubicin resistance antibodyGP170 antibodyMDR 1 antibodyMDR1 antibodyMDR1_HUMAN antibodyMultidrug resistance 1 antibodyMultidrug resistance protein 1 antibodyP glycoprotein 1 antibodyP gp antibodyP-glycoprotein 1 antibodyPGY1 antibody
        see all

      References for Anti-P Glycoprotein antibody [JSB-1], prediluted (ab51893)

      ab51893 has not yet been referenced specifically in any publications.

      Publishing research using ab51893 ? Please let us know so that we can cite the reference in this datasheet

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      Submit an Abreview for ab51893 Submit a Question for ab51893

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      10
      Votes: Highest First

      May be you misleaded what I mean.In fact, I just want to know usual the usual expiry date of your antibodies.lol

      Thank you for contacting Abcam. With proper storage, this product will be stable for 1 year after date purchase. I hope this information helps. Please contact us if you have any questions or there are other ways that we may help you.

      Can you tell me the Guarantee Period of antibodies of your company?For example,ab51893 and ab3366? Thanks!

      At Abcam, providing quality service is just as important as providing quality products. Our Abpromise® ensures that you can trust our products to perform as stated on the datasheets, or we will offer a replacement, credit, or refund. The Abcam Abpromi...

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      The lot number is GR27540-1. Thank you very much. I want to know the production date of my ab51893 because I can't find it on the bottle and Product Manual. Neither of the agency can tell it. Could you tell me how to find out? like the lot number? ...

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      Thank you for contacting us. Lot GR27540-1 was created on the 24th of January 2011. I hope this information is helpful to you. Please do not hesitate to contact us if you need any more advice or information.

      I want to know the production date of my ab51893 because I can't find it on the bottle and Product Manual. Neither of the agency can tell it.  Could you tell me how to find out? like the lot number? Thanks！  

      Thank you for contacting Abcam regarding this. If you can sent us the lot number, I could find that information for you. Please feel free to contact me if you have further questions or if there is anything else we can do to help you to reach your rese...

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      ab51893 THANKS!

      Thank you very much for your interest in ab51893. To our knowledge, ab51893 has not been tested in ICC/IF. Therefore, I can offer a discount off a future purchase if you buy ab51893 now, test it in ICC/IF and submit feedback to us in the form of an Ab...

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      Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"