Anti-P Glycoprotein antibody [JSB-1], prediluted (ab51893)

Overview

  • Product nameAnti-P Glycoprotein antibody [JSB-1], predilutedSee all P Glycoprotein primary antibodies ...
  • Description
    Mouse monoclonal [JSB-1] to P Glycoprotein, prediluted
  • Tested applicationsIHC-Pmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Chinese hamster ovary cell line (CHrC5) expressing Human MDR (170-180 kDa Glykoprotein)

  • Positive control
    • Human liver or renal carcinoma.

Properties

Applications

Our Abpromise guarantee covers the use of ab51893 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P
  • Application notesIHC-P: we recommend using 100µl working solution per test and incubating the antibody for 60 mins at room temperature. Antigen unmasking required for paraffin embedded sections.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • FunctionEnergy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells.
    • Tissue specificityExpressed in liver, kidney, small intestine and brain.
    • Involvement in diseaseGenetic variations in ABCB1 are associated with susceptibility to inflammatory bowel disease type 13 (IBD13) [MIM:612244]. Inflammatory bowel disease is characterized by a chronic relapsing intestinal inflammation. It is subdivided into Crohn disease and ulcerative colitis phenotypes. Crohn disease may involve any part of the gastrointestinal tract, but most frequently the terminal ileum and colon. Bowel inflammation is transmural and discontinuous; it may contain granulomas or be associated with intestinal or perianal fistulas. In contrast, in ulcerative colitis, the inflammation is continuous and limited to rectal and colonic mucosal layers; fistulas and granulomas are not observed. Both diseases include extraintestinal inflammation of the skin, eyes, or joints. Crohn disease and ulcerative colitis are commonly classified as autoimmune diseases.
    • Sequence similaritiesBelongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily.
      Contains 2 ABC transmembrane type-1 domains.
      Contains 2 ABC transporter domains.
    • Cellular localizationMembrane.
    • Information by UniProt
    • Database links
    • Alternative names
      • ABC20 antibody
      • ABCB1 antibody
      • ATP binding cassette sub family B MDR/TAP member 1 antibody
      • ATP binding cassette, sub family B (MDR/TAP), member 1 antibody
      • ATP-binding cassette sub-family B member 1 antibody
      • CD243 antibody
      • CD243 antigen antibody
      • CLCS antibody
      • Colchicin sensitivity antibody
      • Doxorubicin resistance antibody
      • GP170 antibody
      • MDR 1 antibody
      • MDR1 antibody
      • MDR1_HUMAN antibody
      • Multidrug resistance 1 antibody
      • Multidrug resistance protein 1 antibody
      • P glycoprotein 1 antibody
      • P gp antibody
      • P-glycoprotein 1 antibody
      • PGY1 antibody
      see all

    References for Anti-P Glycoprotein antibody [JSB-1], prediluted (ab51893)

    ab51893 has not yet been referenced specifically in any publications.

    Product Wall

    Thank you for contacting Abcam. With proper storage, this product will be stable for 1 year after date purchase. I hope this information helps. Please contact us if you have any questions or there are other ways that we may help you.

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    Thank you for contacting us. Lot GR27540-1 was created on the 24th of January 2011. I hope this information is helpful to you. Please do not hesitate to contact us if you need any more advice or information.

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    Thank you very much for your interest in ab51893. To our knowledge, ab51893 has not been tested in ICC/IF. Therefore, I can offer a discount off a future purchase if you buy ab51893 now, test it in ICC/IF and submit feedback to us in the form of an...

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