Anti-P Glycoprotein antibody [UIC2] (Phycoerythrin) (ab93590)
- Product nameAnti-P Glycoprotein antibody [UIC2] (Phycoerythrin)See all P Glycoprotein primary antibodies ...
- DescriptionMouse monoclonal [UIC2] to P Glycoprotein (Phycoerythrin)
- Tested applicationsFlow Cyt more details
- Species reactivityReacts with: Human
Mouse Balb/c 3T3 fibroblasts transfected with Human P Glycoprotein cDNA
- Positive control8226 DOX40 and 8226/S cell lines
- Storage instructionsStore at +4°C in the dark. Do not freeze.
- Storage bufferPreservative: 0.09% Sodium Azide
- Concentration information loading...
- PurityProtein G purified
- Primary antibody notes ab93590 has been reported to inhibit MDR1-mediated efflux.
- Clonality Monoclonal
- Clone numberUIC2
- Research Areas
Our Abpromise guarantee covers the use of ab93590 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
- FunctionEnergy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells.
- Tissue specificityExpressed in liver, kidney, small intestine and brain.
- Involvement in diseaseGenetic variations in ABCB1 are associated with susceptibility to inflammatory bowel disease type 13 (IBD13) [MIM:612244]. Inflammatory bowel disease is characterized by a chronic relapsing intestinal inflammation. It is subdivided into Crohn disease and ulcerative colitis phenotypes. Crohn disease may involve any part of the gastrointestinal tract, but most frequently the terminal ileum and colon. Bowel inflammation is transmural and discontinuous; it may contain granulomas or be associated with intestinal or perianal fistulas. In contrast, in ulcerative colitis, the inflammation is continuous and limited to rectal and colonic mucosal layers; fistulas and granulomas are not observed. Both diseases include extraintestinal inflammation of the skin, eyes, or joints. Crohn disease and ulcerative colitis are commonly classified as autoimmune diseases.
- Sequence similaritiesBelongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily.
Contains 2 ABC transmembrane type-1 domains.
Contains 2 ABC transporter domains.
- Cellular localizationMembrane.
- ABC20 antibodyABCB1 antibodyATP binding cassette, sub family B (MDR/TAP), member 1 antibody
- ATP-binding cassette sub-family B member 1 antibodyCD243 antibodyCLCS antibodyColchicin sensitivity antibodyDoxorubicin resistance antibodyGP170 antibodyMDR1 antibodyMDR1_HUMAN antibodyMultidrug resistance 1 antibodyMultidrug resistance protein 1 antibodyP glycoprotein 1 antibodyP gp antibodyP-glycoprotein 1 antibodyPGY1 antibody
Anti-P Glycoprotein antibody [UIC2] (Phycoerythrin) images
Staining of the 8226/S (blue histogram) and 8226 DOX40 (purple histogram) cell lines with PE Mouse IgG2a, K Isotype Control (left) or ab93590 (right). Total viable cells were used for analysis.
References for Anti-P Glycoprotein antibody [UIC2] (Phycoerythrin) (ab93590)
This product has been referenced in:
- Chaudhary PM et al. Expression and activity of the multidrug resistance P-glycoprotein in human peripheral blood lymphocytes. Blood 80:2735-9 (1992). Read more (PubMed: 1360267) »
- Mechetner EB & Roninson IB Efficient inhibition of P-glycoprotein-mediated multidrug resistance with a monoclonal antibody. Proc Natl Acad Sci U S A 89:5824-8 (1992). Read more (PubMed: 1352877) »