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Overview

  • Product nameP5CS protein (His-DHFR tag)
  • Protein descriptionRecombinant fragment corresponding to amino acids 10-257 of Human P5CS with a N terminal His-DFHR tag; predicted MWt 27.4 kDa excluding tag (P54886; BC117240).
  • Uniprot accessionP54886
  • Molecular weight27.400kDa
  • Protein length248 amino acids
  • Expression hostE. coli

    • Properties

  • Purity> 95 % Purified via His tag
  • Purification notesPurity is >95% by SDS-PAGE.
  • E.C. Number2.7.2.11
  • FormLyophilised:Reconstitute with 100ul of water.
  • Storage instructionsShipped at 4°C. Store at -20ºC.
  • Storage bufferConstituents: 0.32% Tris HCl, 0.58% Sodium chloride
  • Concentration information loading...
  • Research Areas

    • Applications

    Our Abpromise guarantee covers the use of ab127829 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    Application Notes
    SDS-PAGE SDS-PAGE: Use at an assay dependent dilution.

    Protein info

    • Alternative names
        2810433K04RikAI429789Aldehyde dehydrogenase 18 family member A1
        Aldehyde dehydrogenase 18A1Aldehyde dehydrogenase family 18 member A1ALDH18A1Delta 1 pyrroline 5 carboxylate synthetaseDelta1 pyrroline 5 carboxlate synthetaseGamma-glutamyl kinaseGamma-glutamyl phosphate reductaseGKGlutamate-5-semialdehyde dehydrogenaseGlutamyl-gamma-semialdehyde dehydrogenaseGPRGSASMGC117316MGC32233P5CSP5CS_HUMANPYCSPyrroline 5 carboxylate synthetase (glutamate gamma semialdehyde synthetase)
      see all
  • PathwayAmino-acid biosynthesis; L-proline biosynthesis; L-glutamate 5-semialdehyde from L-glutamate: step 1/2.
    Amino-acid biosynthesis; L-proline biosynthesis; L-glutamate 5-semialdehyde from L-glutamate: step 2/2.
  • Involvement in diseaseDefects in ALDH18A1 are the cause of mental retardation-joint hypermobility-skin laxity with or without metabolic abnormalities (MRJHSL) [MIM:612652]. Clinical manifestations include microcephaly, progressive neurologic dysfunction, mental retardation, progeroid appearance, joint hypermobility, skin laxity and hyperelasticity, cataracts. Some patients manifest metabolic disturbances such as hyperammonemia, hypoornithinemia, hypocitrullinemia, hypoargininemia and hypoprolinemia.
  • Sequence similaritiesIn the N-terminal section; belongs to the glutamate 5-kinase family.
    In the C-terminal section; belongs to the gamma-glutamyl phosphate reductase family.
  • Cellular localizationMitochondrion inner membrane.

    • Target information above from: UniProt accession P54886 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt

    References for P5CS protein (His-DHFR tag) (ab127829)

    ab127829 has not yet been referenced specifically in any publications.

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