Anti-APP-1 antibody (ab101492)
Key features and details
- Rabbit polyclonal to APP-1
- Suitable for: IHC-P
- Reacts with: Mouse, Human
- Isotype: IgG
Overview
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Product name
Anti-APP-1 antibody
See all APP-1 primary antibodies -
Description
Rabbit polyclonal to APP-1 -
Host species
Rabbit -
Tested applications
Suitable for: IHC-Pmore details -
Species reactivity
Reacts with: Mouse, Human
Predicted to work with: Rat, Horse, Guinea pig, Cow, Dog, Pig, Chimpanzee, Rhesus monkey, Gorilla, Orangutan, Platypus -
Immunogen
Synthetic peptide corresponding to Human APP-1 aa 525-575 (internal sequence).
Database link: NP_003810.1 -
Positive control
- Human Bladder Cell Carcinoma, Breast Carcinoma, Colon Carcinoma, Ovarian Carcinoma and Prostate Carcinoma. Mouse Teratoma.
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General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. -
Storage buffer
pH: 6.8
Preservative: 0.09% Sodium azide
Constituents: 0.1% BSA, Tris buffered saline -
Concentration information loading...
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Purity
Immunogen affinity purified -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab101492 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
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IHC-P |
1/100 - 1/500. Antigen retrieval is recommended.
Antigen retrieval with citrate buffer will enhance staining.
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Notes |
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IHC-P
1/100 - 1/500. Antigen retrieval is recommended. Antigen retrieval with citrate buffer will enhance staining. |
Target
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Function
Binds the poly(A) tail of mRNA. May be involved in cytoplasmic regulatory processes of mRNA metabolism. Can probably bind to cytoplasmic RNA sequences other than poly(A) in vivo. -
Tissue specificity
Expressed at low levels in resting normal T cells; following T-cell activation, however, mRNA levels are rapidly up-regulated. -
Sequence similarities
Belongs to the polyadenylate-binding protein type-1 family.
Contains 1 PABC domain.
Contains 4 RRM (RNA recognition motif) domains. -
Post-translational
modificationsArg-518 is dimethylated, probably to asymmetric dimethylarginine. -
Cellular localization
Cytoplasm. Localized in cytoplasmic mRNP granules containing untranslated mRNAs. - Information by UniProt
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Database links
- Entrez Gene: 8761 Human
- Entrez Gene: 230721 Mouse
- Entrez Gene: 298510 Rat
- Omim: 603407 Human
- SwissProt: Q13310 Human
- Unigene: 169900 Human
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Alternative names
- Activated platelet protein 1 antibody
- Activated-platelet protein 1 antibody
- APP 1 antibody
see all
Images
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ab101492 at 1/250 dilution staining APP-1 in a Formalin-fixed, paraffin-embedded section of Human ovarian carcinoma by Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections). Detection utilised DAB.
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ab101492 at 1/250 dilution staining APP-1 in a formalin-fixed, paraffin-embedded section of mouse teratoma by Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections). Detection utilised DAB.
Datasheets and documents
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SDS download
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Datasheet download
References (1)
ab101492 has been referenced in 1 publication.
- Hartmann H et al. Proteomics and C9orf72 neuropathology identify ribosomes as poly-GR/PR interactors driving toxicity. Life Sci Alliance 1:e201800070 (2018). PubMed: 30456350