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Anti-PABPC4 antibody (ab76763)

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Overview

Product name

Anti-PABPC4 antibody
See all PABPC4 products (3) ...

Description

Rabbit polyclonal to PABPC4

Tested applications

WBmore details

Cross reactivity

Reacts with

Human

Predicted to work with

Mouse, Rat

Immunogen

Synthetic peptide derived from internal domain of human PABPC4 protein

Properties

Form

Liquid

Storage instructions

Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Storage buffer

Preservative: None
Constituents: Whole serum

Purity

Whole antiserum

Clonality

Polyclonal

Isotype

IgG

Research areas

Epigenetics and Nuclear Signaling >> Chromatin Binding Proteins >> DNA / RNA binding
Epigenetics and Nuclear Signaling >> DNA / RNA >> RNA Processing >> Other
Epigenetics and Nuclear Signaling >> DNA / RNA >> Translation >> Regulation

Applications

Show applications key

Our Abpromise guarantee covers the use of ab76763 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

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    WB

     WB: 1/500 - 1/5000.Predi...Read more →

    WB: 1/500 - 1/5000.Predicted molecular weight: 71 kDa.

Target

Relevance

Poly(A)-binding proteins (PABPs) bind to the poly(A) tail present at the 3-prime ends of most eukaryotic mRNAs. PABPC4 or IPABP (inducible PABP) was isolated as an activation-induced T-cell mRNA encoding a protein. Activation of T cells increased PABPC4 mRNA levels in T cells approximately 5-fold. PABPC4 contains 4 RNA-binding domains and a proline-rich C terminus. PABPC4 is localized primarily to the cytoplasm. It is suggested that PABPC4 might be necessary for regulation of stability of labile mRNA species in activated T cells. PABPC4 was also identified as an antigen, APP1 (activated-platelet protein-1), expressed on thrombin-activated rabbit platelets. PABPC4 may also be involved in the regulation of protein translation in platelets and megakaryocytes or may participate in the binding or stabilization of polyadenylates in platelet dense granules.

Cellular localization

Cytoplasmic

Alternative names

  • Activated platelet protein 1 antibody
  • APP 1 antibody
  • APP1 antibody
  • Inducible poly(A) binding protein antibody
  • IPABP antibody
  • IPABP4 antibody
  • PABP 4 antibody
  • PABP4 antibody
  • PABPC 4 antibody
  • Poly A binding protein cytoplasmic 4 antibody
  • Poly(A) binding protein 4 antibody
  • Poly(A) binding protein cytoplasmic 4 (inducible form) antibody
  • Poly(A) binding protein cytoplasmic 4 antibody
  • Polyadenylate binding protein 4 antibody
see all

Database links

References for Anti-PABPC4 antibody (ab76763)

ab76763 has not yet been referenced specifically in any publications.

Publishing research using ab76763? Please let us know so that we can cite the reference in this datasheet

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"