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Product Name
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PADI2 / PAD2 antibody
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See all PADI2 / PAD2 antibodies (4)...
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Product type
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Primary antibodies
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Description
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Rabbit polyclonal to PADI2 / PAD2
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Immunogen
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A 15 amino acid synthetic peptide derived from the C-terminal domain of human PADI2 / PAD2.
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Reacts with
(species key)
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Hu, Ms, Rat
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Specificity
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This antibody reacts specifically with the 76 kDa PADI2 / PAD2 protein. It shows no cross reactivity with the other isoforms.
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Tested applications
(see key)
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Flow Cyt, IHC-P, WB
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Abreviews
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Application notes
(see key)
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Recommended dilutions
Flow Cyt: 1/100.
IHC-P: 1/100 - 1/1000.
WB: 1/200. Predicted molecular weight: 76 kDa.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
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Cellular localization
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Cytoplasmic and Nuclear
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Research areas
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Chromatin and Nuclear Signaling >> Chromatin Modifying Enzymes >> Methylation >> Arginine Deimination
Chromatin and Nuclear Signaling >> Chromatin Modifying Enzymes >> Arginine Deiminases
Signal Transduction >> Metabolism >> Amino Acids
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Relevance
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PADI2 / PAD2 is a member of the peptidyl arginine deiminase family of enzymes, which catalyze the post translational deimination of proteins by converting arginine residues into citrullines in the presence of calcium ions. Each family member has a distinct substrate specificity and tissue expression pattern. The type II enzyme is the most widely expressed family member. Known substrates for this enzyme include myelin basic protein in the central nervous system and vimentin in skeletal muscle and macrophages. This enzyme is thought to play a role in the onset and progression of neurodegenerative disorders, including Alzheimers disease and multiple sclerosis, and it has also been implicated in the pathogenesis of glaucoma.
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Database links
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The links below go to external sites and will open in a new browser window |
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Raised in
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Rabbit
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Clonality
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Polyclonal
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Isotype
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IgG
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Purity
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Whole antiserum
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Storage buffer
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Preservative: None
Constituents: Whole serum
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Form
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Liquid
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Concentration
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Concentration not determined - why is this?
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Storage instructions
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Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
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At Abcam, we have one centralized database to hold all of our product information, so that everything we know about this PADI2 / PAD2 antibody is on this datasheet. But please do contact us if you would like any reassurance! |
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Search PubMed (MEDLINE) for references to PADI2 / PAD2
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PADI2 / PAD2 antibody - more information
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Customer reviews (feedback) regarding PADI2 / PAD2 antibody |
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PADI2 / PAD2 antibody - other tools:
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Contact Abcam with a Technical Enquiry about PADI2 / PAD2 antibody |
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