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Western blot - PADI2 / PAD2 antibody (ab56928)
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Product Name
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PADI2 / PAD2 antibody
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See all PADI2 / PAD2 antibodies (4)...
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Product type
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Primary antibodies
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Description
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Mouse monoclonal to PADI2 / PAD2
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Immunogen
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Recombinant fragment, corresponding to amino acids 1-109 of Human PADI2 / PAD2
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Reacts with
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Hu
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Tested applications
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WB
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Abreviews
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Application notes
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Recommended dilutions
WB: Use at a concentration of 1-5 µg/ml.
This antibody has only been tested in WB against the recombinant fragment used as immunogen. We have no data on the detection of endogenous protein.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
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Cellular localization
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Cytoplasmic and Nuclear
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Research areas
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Chromatin and Nuclear Signaling >> Chromatin Modifying Enzymes >> Methylation >> Arginine Deimination
Chromatin and Nuclear Signaling >> Chromatin Modifying Enzymes >> Arginine Deiminases
Signal Transduction >> Metabolism >> Amino Acids
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Relevance
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PADI2 / PAD2 is a member of the peptidyl arginine deiminase family of enzymes, which catalyze the post translational deimination of proteins by converting arginine residues into citrullines in the presence of calcium ions. Each family member has a distinct substrate specificity and tissue expression pattern. The type II enzyme is the most widely expressed family member. Known substrates for this enzyme include myelin basic protein in the central nervous system and vimentin in skeletal muscle and macrophages. This enzyme is thought to play a role in the onset and progression of neurodegenerative disorders, including Alzheimers disease and multiple sclerosis, and it has also been implicated in the pathogenesis of glaucoma.
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Database links
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The links below go to external sites and will open in a new browser window |
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Raised in
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Mouse
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Clonality
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Monoclonal
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Isotype
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IgG1
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Light chain type
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kappa
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Purity
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Protein G purified
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Storage buffer
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Preservative: None
PBS, pH 7.2
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Form
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Liquid
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Concentration
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0.500 mg/ml
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Storage instructions
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Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
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At Abcam, we have one centralized database to hold all of our product information, so that everything we know about this PADI2 / PAD2 antibody is on this datasheet. But please do contact us if you would like any reassurance! |
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PADI2 / PAD2 antibody images:
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 Western blot - PADI2 / PAD2 antibody (ab56928)
Western blot against tagged recombinant protein immunogen using ab56928 PADI2 / PAD2 antibody at 1ug/ml. Predicted band size of immunogen is 38 kDa
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Search PubMed (MEDLINE) for references to PADI2 / PAD2
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PADI2 / PAD2 antibody - more information
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