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Anti-PADI4 / PAD4 antibody (ab24007)

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    Overview

    Product name

    Anti-PADI4 / PAD4 antibody
    See all PADI4 / PAD4 products (8) ...

    Description

    Rabbit polyclonal to PADI4 / PAD4

    Specificity

    Antibody may cross react with all PADI4 / PAD4 isoforms.

    Tested applications

    WBmore details

    Cross reactivity

    Reacts with

    Human

    Immunogen

    A 15 residue synthetic peptide derived from a domain common to human PADI4 / PAD4 proteins.

    Properties

    Form

    Liquid

    Storage instructions

    Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze / thaw cycles.

    Storage buffer

    Preservative: None
    Constituents: Whole serum

    Purity

    Whole antiserum

    Clonality

    Polyclonal

    Isotype

    IgG

    Research areas

    Epigenetics and Nuclear Signaling >> Chromatin Modifying Enzymes >> Methylation >> Arginine Deimination
    Epigenetics and Nuclear Signaling >> Chromatin Modifying Enzymes >> Arginine Deiminases
    Signal Transduction >> Metabolism >> Amino Acids

    Applications

    Show applications key

    Our Abpromise guarantee covers the use of ab24007 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    Target

    Relevance

    In vivo expression of PADI4 correlates with the appearance of citrulline in histones. It has been demonstrated that PADI4 converts arginines in the histone H3 tail to citrulline, blocks transcriptional activation and is recruited to the endogenous promotor. PADI4 represents a novel class of histone modifying enzymes probably linked to oestrogen regulated transcription. PADI4 is thought to be a rheumatoid arthritis susceptibility locus, and could have an important role in the pathogenesis of rheumatoid arthritis by increasing citrullination of proteins in rheumatoid arthritis synovial tissues, leading, in a cytokine-rich milieu, to a break in tolerance to citrullinated peptides processed and presented in the appropriate HLA context.

    Cellular localization

    Cytoplasm. Nucleus. Cytoplasmic granule. Note: Cytoplasmic granules of eosinophils and neutrophils.

    Alternative names

    • EC 3.5.3.15 antibody
    • HL 60 PAD antibody
    • PAD 4 antibody
    • PAD antibody
    • PADI 4 antibody
    • PADI 5 antibody
    • PADI H protein antibody
    • PADI5 antibody
    • PDI 4 antibody
    • PDI 5 antibody
    • PDI4 antibody
    • PDI5 antibody
    • peptidyl arginine deiminase type III antibody
    • Peptidyl arginine deiminase type IV antibody
    • Peptidyl arginine deiminase type V antibody
    • Peptidylarginine deiminase antibody
    • Peptidylarginine deiminase IV antibody
    • Peptidylarginine deiminase type VI antibody
    • Protein arginine deiminase antibody
    • Protein arginine deiminase type 4 antibody
    • Protein arginine deiminase type IV antibody
    see all

    Database links

    References for Anti-PADI4 / PAD4 antibody (ab24007)

    ab24007 has not yet been referenced specifically in any publications.

    Publishing research using ab24007? Please let us know so that we can cite the reference in this datasheet

    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"