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Products:Signal Transduction >> Metabolism >> Amino Acids
Overview
Product name
PADI4 / PAD4 peptide (2-14)
See all PADI4 / PAD4 products (2) ...
Protein description
Synthetic peptide: AQGTLIRVTPEQP-C, corresponding to amino acids 2-14 of Human PADI4 / PAD4 This peptide was used as an immunogen for ab26071 - PADI4 / PAD4 antibody.
Properties
Form
Liquid
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Concentration
Concentration information loading...
Sequence
AQGTLIRVTP EQP-C
Applications
Application notes
This peptide can be used with studies using ab26071.
Protein info
Relevance
In vivo expression of PADI4 correlates with the appearance of citrulline in histones. It has been demonstrated that PADI4 converts arginines in the histone H3 tail to citrulline, blocks transcriptional activation and is recruited to the endogenous promotor. PADI4 represents a novel class of histone modifying enzymes probably linked to oestrogen regulated transcription. PADI4 is thought to be a rheumatoid arthritis susceptibility locus, and could have an important role in the pathogenesis of rheumatoid arthritis by increasing citrullination of proteins in rheumatoid arthritis synovial tissues, leading, in a cytokine-rich milieu, to a break in tolerance to citrullinated peptides processed and presented in the appropriate HLA context.
Cellular localization
Cytoplasm. Nucleus. Cytoplasmic granule. Note: Cytoplasmic granules of eosinophils and neutrophils.
References for PADI4 / PAD4 peptide (2-14) (ab30475)
ab30475 has not yet been referenced specifically in any publications.
Publishing research using ab30475? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"