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Products:Epigenetics and Nuclear Signaling >> Transcription >> Polymerase associated factors >> Pol II Transcription >> Polymerase
Overview
Product name
Anti-PAF1 antibody
See all PAF1 products (4) ...
Description
Rabbit polyclonal to PAF1
Tested applications
Cross reactivity
Reacts with
Human
Predicted to work with
Mouse
Immunogen
Synthetic peptide corresponding to a region between residues 475 and 525 of Human PAF1 (TrEMBL entry Q9NUU9)
Positive control
Whole cell lysate from 293T cells
Properties
Form
Liquid
Storage instructions
Store at +4°C.
Storage buffer
Preservative: 0.1% Sodium Azide
Constituents: 8mM PBS, 60mM Citrate, 150mM Tris, pH 7-8
Concentration
Concentration information loading...
Purity
Immunogen affinity purified
Clonality
Polyclonal
Isotype
IgG
Research areas
Epigenetics and Nuclear Signaling >> Transcription >> Elongation factors
Epigenetics and Nuclear Signaling >> Transcription >> Cancer susceptibility >> Proto-oncogenes
Epigenetics and Nuclear Signaling >> Transcription >> Polymerase associated factors >> Pol II Transcription >> Polymerase
Applications
Show applications key
Our Abpromise guarantee covers the use of ab70638 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
IP: Use at 3-10 µg/mg of lysate.
Target
Relevance
In yeast, PAF1 acts as a docking protein and is involved in transcriptional elongation through interactions with RNA polymerase II and other members of the transcription machinery. The human homolog has also been shown to interact with RNA polymerase II, in particular with the form which is phosphorylated on Serine 2 or 5 in the carboxy-terminal domain (CTD). It also associates with HRPT2 (parafibromin) and other members of the PAF1 complex (LEO1 and CTR9). This complex is involved in transcriptional elongation and 3' end processing. There is evidence that overexpression of PAF1 is involved in cancer development.
Cellular localization
Nuclear
Alternative names
- F23149 1 antibody
- FLJ11123 antibody
- PAF 1 antibody
see all
Database links
- Entrez Gene: 54623 Human
- Entrez Gene: 54624 Mouse
- Omim: 610506 Human
- SwissProt: Q9H166 Human
- SwissProt: P55098 Mouse
- SwissProt: Q8K2T8 Mouse
- Unigene: 466714 Human
References for Anti-PAF1 antibody (ab70638)
ab70638 has not yet been referenced specifically in any publications.
Publishing research using ab70638? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"