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Read our guarantee »Products:Epigenetics and Nuclear Signaling >> Transcription >> Polymerase associated factors >> Pol II Transcription >> Polymerase
Anti-PAF1 antibody
See all PAF1 products (4) ...
Rabbit polyclonal to PAF1
Reacts with
Human
Predicted to work with
Mouse
Synthetic peptide corresponding to a region between residues 475 and 525 of Human PAF1 (TrEMBL entry Q9NUU9)
Whole cell lysate from 293T cells
Liquid
Store at +4°C.
Preservative: 0.1% Sodium Azide
Constituents: 8mM PBS, 60mM Citrate, 150mM Tris, pH 7-8
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Immunogen affinity purified
Polyclonal
IgG
Epigenetics and Nuclear Signaling >> Transcription >> Elongation factors
Epigenetics and Nuclear Signaling >> Transcription >> Cancer susceptibility >> Proto-oncogenes
Epigenetics and Nuclear Signaling >> Transcription >> Polymerase associated factors >> Pol II Transcription >> Polymerase
Our Abpromise guarantee covers the use of ab70638 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
IP: Use at 3-10 µg/mg of lysate.
In yeast, PAF1 acts as a docking protein and is involved in transcriptional elongation through interactions with RNA polymerase II and other members of the transcription machinery. The human homolog has also been shown to interact with RNA polymerase II, in particular with the form which is phosphorylated on Serine 2 or 5 in the carboxy-terminal domain (CTD). It also associates with HRPT2 (parafibromin) and other members of the PAF1 complex (LEO1 and CTR9). This complex is involved in transcriptional elongation and 3' end processing. There is evidence that overexpression of PAF1 is involved in cancer development.
Nuclear
ab70638 has not yet been referenced specifically in any publications.
Publishing research using ab70638? Please let us know so that we can cite the reference in this datasheet
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