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Product Name
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PAI1 antibody
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See all PAI1 / Serpine 1 antibodies (20)...
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Product type
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Primary antibodies
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Description
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Rabbit polyclonal to PAI1
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Immunogen
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Recombinant full length PAI1 protein (Mouse).
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Reacts with
(species key)
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Ms
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Tested applications
(see key)
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IHC-Fr, IHC-P, WB
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Abreviews
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Application notes
(see key)
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Recommended dilutions
IHC-P: Use at a concentration of 1 - 10 µg/ml.
IHC-Fr: Use at an assay dependent dilution (PMID 18276785).
WB: Use at a concentration of 1-5 µg/ml. Predicted molecular weight: 45 kDa.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
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Positive control
(see definition)
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Paraffin sections of lung and carotid.
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Cellular localization
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Secreted
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Research areas
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Cancer >> Tumor biomarkers >> Other
Cell Biology >> Proteolysis / Ubiquitin >> Protease inhibitors >> Serine protease inhibitors >> SERPINs
Cardiovascular >> Blood >> Fibrinolysis / Thrombolysis
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Relevance
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PAI1 (plasminogen activator inhibitor 1) is originally cloned from human endothelial cell (Pannekoek 1986, Ginsburg 1986) and rat hepatoma cell 3 cDNA libraries. As a member of the serpin family of serine protease inhibitors, PAI1 inhibits both tissue type palsminogen activator (tPA) and urokinase type plasminogen activator (uPA). High PAI1 levels are associated with an increased risk of thromboembolic disease while PAI1 deficiency may represent an inherited autosomal recessive bleeding disorder.
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Database links
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The links below go to external sites and will open in a new browser window Entrez Gene | | 18787 (Mouse)
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Raised in
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Rabbit
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Clonality
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Polyclonal
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Isotype
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IgG
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Purity
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Protein A purified
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Storage buffer
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Preservative: None
Constituents: 0.1M Sodium chloride, 0.05M Sodium phosphate, 1mM EDTA. pH 6.6. Material safety datasheet (MSDS) for this product:
Sodium Phosphate MSDS
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Purification notes
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This is an IgG purified fraction (purified by Protein A Sepharose).
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Form
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Liquid
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Concentration
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9.300 mg/ml
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Storage instructions
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Aliquot and store at -80°C. Avoid repeated freeze / thaw cycles.
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At Abcam, we have one centralized database to hold all of our product information, so that everything we know about this PAI1 antibody is on this datasheet. But please do contact us if you would like any reassurance! |
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References for PAI1 antibody (ab28207)
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This product has been used in: (two most recent references)
Basu A et al. Plasminogen activator inhibitor-1 (PAI-1) facilitates retinal angiogenesis in a model of oxygen-induced retinopathy. Invest Ophthalmol Vis Sci 50:4974-81 (2009). IHC-Fr; Mouse. PubMed: 19443721
Milliat F et al. Essential role of plasminogen activator inhibitor type-1 in radiation enteropathy. Am J Pathol 172:691-701 (2008). IHC-Fr; Mouse. PubMed: 18276785
If you publish research using ab28207 please let us know so that we can cite the reference on this datasheet.
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Search PubMed (MEDLINE) for references to PAI1
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PAI1 antibody - more information
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Customer reviews (feedback) regarding PAI1 antibody |
Customer FAQs regarding PAI1 antibody |
Protocols for PAI1 antibody |
Price and availability of products related to PAI1 antibody |
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Contact Abcam with a Technical Enquiry about PAI1 antibody |
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