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Western blot - PAI1 antibody (ab7205)
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Product Name
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PAI1 antibody
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See all PAI1 / Serpine 1 antibodies (20)...
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Product type
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Primary antibodies
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Description
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Rabbit polyclonal to PAI1
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Immunogen
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Recombinant full length protein (Rat).
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Reacts with
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Ms, Rat
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Tested applications
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ICC, WB
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Abreviews
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Application notes
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Recommended dilutions
ICC: 1/200 (PMID 19036760).
WB: 1/1000.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
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Cellular localization
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Secreted
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Research areas
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Cancer >> Tumor biomarkers >> Other
Cell Biology >> Proteolysis / Ubiquitin >> Protease inhibitors >> Serine protease inhibitors >> SERPINs
Cardiovascular >> Blood >> Fibrinolysis / Thrombolysis
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Relevance
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PAI1 (plasminogen activator inhibitor 1) is originally cloned from human endothelial cell (Pannekoek 1986, Ginsburg 1986) and rat hepatoma cell 3 cDNA libraries. As a member of the serpin family of serine protease inhibitors, PAI1 inhibits both tissue type palsminogen activator (tPA) and urokinase type plasminogen activator (uPA). High PAI1 levels are associated with an increased risk of thromboembolic disease while PAI1 deficiency may represent an inherited autosomal recessive bleeding disorder.
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Database links
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The links below go to external sites and will open in a new browser window |
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Raised in
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Rabbit
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Clonality
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Polyclonal
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Isotype
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IgG
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Purity
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Protein A purified
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Storage buffer
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Preservative: 0.1% Sodium Azide
Constituents: PBS Material safety datasheet (MSDS) for this product:
Sodium Azide MSDS
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Form
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Liquid
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Concentration
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1.000 mg/ml
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Storage instructions
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Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
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At Abcam, we have one centralized database to hold all of our product information, so that everything we know about this PAI1 antibody is on this datasheet. But please do contact us if you would like any reassurance! |
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See below for PAI1 antibody images, references, products related to ab7205 and other tools.
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PAI1 antibody images:
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 Western blot - PAI1 antibody (ab7205)
PAI1 antibody (ab7205) at 1/1000 dilution
Rat PAI1 detected by Western blot on Day 3 in a glomerular nephritis model.
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References for PAI1 antibody (ab7205)
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This product has been used in: (two most recent references)
Artaza JN & Norris KC Vitamin D reduces the expression of collagen and key profibrotic factors by inducing an antifibrotic phenotype in mesenchymal multipotent cells. J Endocrinol 200:207-21 (2009). WB, ICC; Mouse. PubMed: 19036760
Artaza JN et al. Myostatin promotes a fibrotic phenotypic switch in multipotent C3H 10T1/2 cells without affecting their differentiation into myofibroblasts. J Endocrinol 196:235-49 (2008). PubMed: 18252947
If you publish research using ab7205 please let us know so that we can cite the reference on this datasheet.
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Search PubMed (MEDLINE) for references to PAI1
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PAI1 antibody - more information
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Customer reviews (feedback) regarding PAI1 antibody |
Customer FAQs regarding PAI1 antibody |
Protocols for PAI1 antibody |
Price and availability of products related to PAI1 antibody |
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PAI1 antibody - related products:
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PAI1 antibody - other tools:
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Contact Abcam with a Technical Enquiry about PAI1 antibody |
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All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"
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