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SDS-PAGE - PAI1 protein (ab53388)
(enlarge)
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Product Name
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PAI1 protein
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Product type
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Proteins and Peptides
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Peptide
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Recombinant fragment, corresponding to amino acids 24-402 of mature Human PAI1 with an aminoterminal hexahistidine tag.
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Tested applications
(see key)
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SDS-PAGE
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Application notes
(see key)
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Recommended dilutions
SDS-PAGE: Use at an assay dependent dilution.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
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Research areas
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Cancer >> Tumor biomarkers >> Other
Cell Biology >> Proteolysis / Ubiquitin >> Protease inhibitors >> Serine protease inhibitors >> SERPINs
Cardiovascular >> Blood >> Fibrinolysis / Thrombolysis
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Relevance
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PAI1 (plasminogen activator inhibitor 1) is originally cloned from human endothelial cell (Pannekoek 1986, Ginsburg 1986) and rat hepatoma cell 3 cDNA libraries. As a member of the serpin family of serine protease inhibitors, PAI1 inhibits both tissue type palsminogen activator (tPA) and urokinase type plasminogen activator (uPA). High PAI1 levels are associated with an increased risk of thromboembolic disease while PAI1 deficiency may represent an inherited autosomal recessive bleeding disorder.
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Purity
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>95% by SDS-PAGE
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Storage buffer
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Preservative: None
Constituents: 50% Glycerol, 20mM Tris, pH 8 Material safety datasheet (MSDS) for this product:
Glycerol MSDS
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Form
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Liquid
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Concentration
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10.000 mg/ml
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Storage instructions
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Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
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Expression system
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E. coli
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Sequence
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VHHPPSY VAHLASDFGV RVFQQVAQAS KDRNVVFSPY
GVASVLAMLQ LTTGGETQQQ IQAAMGFKID DKGMAPALRH LYKELMGPWN KDEISTTDAI
FVQRDLKLVQ GFMPHFFRLF RSTVKQVDFS EVERARFIIN DWVKTHTKGM ISNLLGKGAV
DQLTRLVLVN ALYFNGQWKT PFPDSSTHRR LFHKSDGSTV SVPMMAQTNK FNYTEFTTPD
GHYYDILELP YHGDTLSMFI AAPYEKEVPL SALTNILSAQ LISHWKGNMT RLPRLLVLPK
FSLETEVDLR KPLENLGMTD MFRQFQADFT SLSDQEPLHV AQALQKVKIE VNESGTVASS
STAVIVSARM APEEIIMDRP FLFVVRHNPT GTVLFMGQVM EP
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At Abcam, we have one centralized database to hold all of our product information, so that everything we know about this PAI1 protein is on this datasheet. But please do contact us if you would like any reassurance! |
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PAI1 protein images:
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 SDS-PAGE - PAI1 protein (ab53388)
SDS page analysis of ab53388
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Search PubMed (MEDLINE) for references to PAI1
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PAI1 protein - more information
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Customer reviews (feedback) regarding PAI1 protein |
Customer FAQs regarding PAI1 protein |
Protocols for PAI1 protein |
Price and availability of products related to PAI1 protein |
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PAI1 protein - other tools:
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Contact Abcam with a Technical Enquiry about PAI1 protein |
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