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PAI1 protein (ab53388)

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Overview

Product name

PAI1 protein
See all PAI1 products (38) ...

Protein description

Recombinant fragment, corresponding to amino acids 24-402 of mature Human PAI1 with an aminoterminal hexahistidine tag.

Expression host

E. coli

Properties

Purity

>95% by SDS-PAGE

Form

Liquid

Storage instructions

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

Storage buffer

Preservative: None
Constituents: 50% Glycerol, 20mM Tris, pH 8

Concentration

Concentration information loading...

Sequence notes

VHHPPSY VAHLASDFGV RVFQQVAQAS KDRNVVFSPY GVASVLAM LQ LTTGGETQQQ IQAAMGFKID DKGMAPALRH LYKELMGPWN KDEISTTDAI FVQRDLKL VQ GFMPHFFRLF RSTVKQVDFS EVERARFIIN DWVKTHTKGM ISNLLGKGAV DQLTRLVL VN ALYFNGQWKT PFPDSSTHRR LFHKSDGSTV SVPMMAQTNK FNYTEFTTPD GHYYDILE LP YHGDTLSMFI AAPYEKEVPL SALTNILSAQ LISHWKGNMT RLPRLLVLPK FSLETEVD LR KPLENLGMTD MFRQFQADFT SLSDQEPLHV AQALQKVKIE VNESGTVASS STAVIVSA RM APEEIIMDRP FLFVVRHNPT GTVLFMGQVM EP

Research areas

Cancer >> Tumor biomarkers >> Other
Cell Biology >> Proteolysis / Ubiquitin >> Protease inhibitors >> Serine protease inhibitors >> SERPINs
Cardiovascular >> Blood >> Fibrinolysis / Thrombolysis

  • SDS-PAGE - PAI1 protein (ab53388)SDS-PAGE - PAI1 protein (ab53388) image (enlarge)

Applications

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Our Abpromise guarantee covers the use of ab53388 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Protein info

Function

This inhibitor acts as 'bait' for tissue plasminogen activator, urokinase, and protein C. Its rapid interaction with TPA may function as a major control point in the regulation of fibrinolysis.

Tissue specificity

Found in plasma and platelets and in endothelial, hepatoma and fibrosarcoma cells.

Involvement in disease

Defects in SERPINE1 are the cause of plasminogen activator inhibitor-1 deficiency (PAI-1D) [MIM:613329]. It is a hematologic disorder characterized by increased bleeding after trauma, injury, or surgery. Affected females have menorrhagia. The bleeding defect is due to increased fibrinolysis of fibrin blood clots due to deficiency of plasminogen activator inhibitor-1, which inhibits tissue and urinary activators of plasminogen.
Note=High concentrations of SERPINE1 seem to contribute to the development of venous but not arterial occlusions.

Sequence similarities

Belongs to the serpin family.

Post-translational
modifications

Inactivated by proteolytic attack of the urokinase-type (u-PA) and the tissue-type (TPA), cleaving the 369-Arg-
-Met-370 bond.

Cellular localization

Secreted.

Target information above from: UniProt accessionP05121 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).

Information by UniProt

PAI1 protein images:

  SDS-PAGE - PAI1 protein (ab53388)

SDS-PAGE - PAI1 protein (ab53388)

SDS page analysis of ab53388

References for PAI1 protein (ab53388)

ab53388 has not yet been referenced specifically in any publications.

Publishing research using ab53388? Please let us know so that we can cite the reference in this datasheet

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"