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Read our guarantee »Products:Epigenetics and Nuclear Signaling >> DNA / RNA >> Translation >> Regulation
Anti-PAIP2 antibody
See all PAIP2 products (2) ...
Rabbit polyclonal to PAIP2
WB, IPmore details
Reacts with
Mouse, Human
Predicted to work with
Rat, Chicken, Cow
Synthetic peptide: DLVISDGSSLEDLVVKS conjugated to KLH via an added cysteine residue, corresponding to amino acids 93-109 of Human PAIP2
DLVISDGSSL EDLVVKS
HeLa cell lysate and mouse embryo extract.
Liquid
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Preservative: 15mM Sodium Azide
Constituents: 0.01M PBS, pH 7.4
Concentration information loading...
Immunogen affinity purified
Polyclonal
IgG
Epigenetics and Nuclear Signaling >> DNA / RNA >> Translation >> Regulation
Our Abpromise guarantee covers the use of ab69861 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
IP: Use at a concentration of 5 - 10 µg/ml.
WB: Use at a concentration of 0.5 - 1 µg/ml. Predicted molecular weight: 15 kDa.
Detection of the PAIP2 band by immunoblotting is specifically inhibited by the
immunizing peptide.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
PAIP2 acts as a repressor in the regulation of translation initiation of poly(A)-containing mRNAs. Its inhibitory activity on translation is mediated via its action on PABPC1. It displaces the interaction of PABPC1 with poly(A) RNA and competes with PAIP1 for binding to PABPC1. Its association with PABPC1 results in disruption of the cytoplasmic poly(A) RNP structure organization (referenced from Swiss-Prot).
Cytoplasmic
ab69861 has not yet been referenced specifically in any publications.
Publishing research using ab69861? Please let us know so that we can cite the reference in this datasheet
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"
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