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Product Name 

PAIP2 antibody

 

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Product type 

Primary antibodies

Description 

Rabbit polyclonal to PAIP2

Immunogen 

Synthetic peptide: DLVISDGSSLEDLVVKS conjugated to KLH via an added cysteine residue, corresponding to amino acids 93-109 of Human PAIP2
BLAST 'DLVISDGSSLEDLVVKS' with BLAST the sequence with ExPASy or BLAST the sequence with NCBI

Reacts with 

Hu, Ms

Predicted to react 
(species key)

Rat, Chk, Cow
(Due to sequence homology)

Tested applications 
(see key)

IP, WB


Abreviews 

Customer reviews
(see key)


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Application notes 
(see key)

Recommended dilutions
IP: Use at a concentration of 5 - 10 µg/ml.
WB: Use at a concentration of 0.5 - 1 µg/ml. Predicted molecular weight: 15 kDa.
Detection of the PAIP2 band by immunoblotting is specifically inhibited by the
immunizing peptide.

Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.

Positive control 
(see definition)

HeLa cell lysate and mouse embryo extract.

Cellular localization 

Cytoplasmic

Research areas 

Chromatin and Nuclear Signaling >> DNA / RNA >> Translation >> Regulation

Relevance 

PAIP2 acts as a repressor in the regulation of translation initiation of poly(A)-containing mRNAs. Its inhibitory activity on translation is mediated via its action on PABPC1. It displaces the interaction of PABPC1 with poly(A) RNA and competes with PAIP1 for binding to PABPC1. Its association with PABPC1 results in disruption of the cytoplasmic poly(A) RNP structure organization (referenced from Swiss-Prot).

 

Alternative names PAIP2 antibody (ab69861)

Database links 

The links below go to external sites and will open in a new browser window

Entrez Gene

    

416187    (Chicken)
51247    (Human)
67869    (Mouse)
361309    (Rat)

Omim

    

605604    (Human)

SwissProt

    

Q3ZC67    (Cow)
Q9BPZ3    (Human)
Q6FID7    (Human)
Q49AE6    (Human)
Q3TJ84    (Mouse)
Q3U438    (Mouse)
Q3UBH5    (Mouse)
Q9D6V8    (Mouse)
Q6AXZ0    (Rat)

Unigene

    

396644    (Human)

Raised in 

Rabbit

Clonality 

Polyclonal

Isotype 

IgG

Purity 

Immunogen affinity purified

Storage buffer 

Preservative: 15mM Sodium Azide
Constituents: 0.01M PBS, pH 7.4

Material safety datasheet (MSDS) for this product:
Sodium Azide MSDS

Form 

Liquid

Concentration 

1.000 mg/ml

Storage instructions 

Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

 

At Abcam, we have one centralized database to hold all of our product information, so that everything we know about this PAIP2 antibody is on this datasheet. But please do contact us if you would like any reassurance!


 

Search PubMed (MEDLINE) for references to PAIP2

 

PAIP2 antibody - more information

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Price and availability of products related to PAIP2 antibody

 

PAIP2 antibody - related products:

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Lysates

 

Positive Controls for PAIP2 antibody

ab29546

  

HeLa (Human epithelial carcinoma cell line) Cytoplasmic Lysate

 

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