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Anti-PAIP2 antibody (ab69861)

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Overview

Product name

Anti-PAIP2 antibody
See all PAIP2 products (2) ...

Description

Rabbit polyclonal to PAIP2

Tested applications

WB, IPmore details

Cross reactivity

Reacts with

Mouse, Human

Predicted to work with

Rat, Chicken, Cow

Immunogen

Synthetic peptide: DLVISDGSSLEDLVVKS conjugated to KLH via an added cysteine residue, corresponding to amino acids 93-109 of Human PAIP2

DLVISDGSSL EDLVVKS

Run BLAST with BLAST the sequence with ExPASyRun BLAST with BLAST the sequence with NCBI

Positive control

HeLa cell lysate and mouse embryo extract.

Properties

Form

Liquid

Storage instructions

Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Storage buffer

Preservative: 15mM Sodium Azide
Constituents: 0.01M PBS, pH 7.4

Concentration

Concentration information loading...

Purity

Immunogen affinity purified

Clonality

Polyclonal

Isotype

IgG

Research areas

Epigenetics and Nuclear Signaling >> DNA / RNA >> Translation >> Regulation

Applications

Show applications key

Our Abpromise guarantee covers the use of ab69861 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • WB

     

  • IP

     

Application notes

IP: Use at a concentration of 5 - 10 µg/ml.
WB: Use at a concentration of 0.5 - 1 µg/ml. Predicted molecular weight: 15 kDa.
Detection of the PAIP2 band by immunoblotting is specifically inhibited by the
immunizing peptide.

Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.

Target

Relevance

PAIP2 acts as a repressor in the regulation of translation initiation of poly(A)-containing mRNAs. Its inhibitory activity on translation is mediated via its action on PABPC1. It displaces the interaction of PABPC1 with poly(A) RNA and competes with PAIP1 for binding to PABPC1. Its association with PABPC1 results in disruption of the cytoplasmic poly(A) RNP structure organization (referenced from Swiss-Prot).

Cellular localization

Cytoplasmic

Alternative names

  • PABP-interacting protein 2 antibody
  • poly(A) binding protein interacting protein 2 antibody

Database links

see all

References for Anti-PAIP2 antibody (ab69861)

ab69861 has not yet been referenced specifically in any publications.

Publishing research using ab69861? Please let us know so that we can cite the reference in this datasheet

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"