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Product Name
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PAIP2 antibody
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See all PAIP2 antibodies (2)...
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Product type
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Primary antibodies
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Description
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Rabbit polyclonal to PAIP2
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Immunogen
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Synthetic peptide: DLVISDGSSLEDLVVKS conjugated to KLH via an added cysteine residue, corresponding to amino acids 93-109 of Human PAIP2
BLAST 'DLVISDGSSLEDLVVKS' with  or 
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Reacts with
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Hu, Ms
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Predicted to react
(species key)
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Rat, Chk, Cow
(Due to sequence homology)
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Tested applications
(see key)
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IP, WB
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Abreviews
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Application notes
(see key)
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Recommended dilutions
IP: Use at a concentration of 5 - 10 µg/ml.
WB: Use at a concentration of 0.5 - 1 µg/ml. Predicted molecular weight: 15 kDa.
Detection of the PAIP2 band by immunoblotting is specifically inhibited by the
immunizing peptide.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
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Positive control
(see definition)
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HeLa cell lysate and mouse embryo extract.
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Cellular localization
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Cytoplasmic
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Research areas
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Chromatin and Nuclear Signaling >> DNA / RNA >> Translation >> Regulation
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Relevance
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PAIP2 acts as a repressor in the regulation of translation initiation of poly(A)-containing mRNAs. Its inhibitory activity on translation is mediated via its action on PABPC1. It displaces the interaction of PABPC1 with poly(A) RNA and competes with PAIP1 for binding to PABPC1. Its association with PABPC1 results in disruption of the cytoplasmic poly(A) RNP structure organization (referenced from Swiss-Prot).
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Database links
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The links below go to external sites and will open in a new browser window |
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Raised in
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Rabbit
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Clonality
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Polyclonal
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Isotype
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IgG
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Purity
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Immunogen affinity purified
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Storage buffer
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Preservative: 15mM Sodium Azide
Constituents: 0.01M PBS, pH 7.4 Material safety datasheet (MSDS) for this product:
Sodium Azide MSDS
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Form
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Liquid
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Concentration
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1.000 mg/ml
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Storage instructions
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Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
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At Abcam, we have one centralized database to hold all of our product information, so that everything we know about this PAIP2 antibody is on this datasheet. But please do contact us if you would like any reassurance! |
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Search PubMed (MEDLINE) for references to PAIP2
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PAIP2 antibody - more information
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