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PAIP2 protein (His tag) (ab40274)

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Overview

Product name

PAIP2 protein (His tag)
See all PAIP2 products (3) ...

Protein description

Recombinant full length protein (Human): PAIP2 with His-Tag at N-terminus.

Expression host

E. coli

Properties

Purity

> 95% by SDS-PAGE

Form

Liquid

Storage instructions

Aliquot and store at -80°C. Avoid repeated freeze / thaw cycles.

Storage buffer

Preservative: 0.002% Sodium Azide, 2.5mM Imidazole.
Constituents: 3mM Sodium chloride, 10mM Tris, pH 8

Concentration

Concentration information loading...

Research areas

Epigenetics and Nuclear Signaling >> DNA / RNA >> Translation >> Regulation

Applications

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Our Abpromise guarantee covers the use of ab40274 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • SDS-PAGE

     

Application notes

SDS-PAGE: Use at an assay dependent dilution.
Mass Spectometry.


Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.

Protein info

Function

Acts as a repressor in the regulation of translation initiation of poly(A)-containing mRNAs. Its inhibitory activity on translation is mediated via its action on PABPC1. Displaces the interaction of PABPC1 with poly(A) RNA and competes with PAIP1 for binding to PABPC1. Its association with PABPC1 results in disruption of the cytoplasmic poly(A) RNP structure organization.

Sequence similarities

Belongs to the PAIP2 family.

Domain

Only the PABPC1-interacting motif-1 (PAM1) interferes with the binding of PABPC1 to poly(A) RNA and translation initiation.

Cellular localization

Cytoplasm.

Target information above from: UniProt accessionQ9BPZ3 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).

Information by UniProt

References for PAIP2 protein (His tag) (ab40274)

ab40274 has not yet been referenced specifically in any publications.

Publishing research using ab40274? Please let us know so that we can cite the reference in this datasheet

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"