| | | | Western blot - PAK1 antibody (ab1178)
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| Product Name | PAK1 antibody |
| | See all PAK1 antibodies (16)... |
| Product type | Primary antibodies |
| Description | Rabbit polyclonal to PAK1 |
| Immunogen | Synthetic peptide: dvekrgsakellqhpflkl, corresponding to amino acids 484-502 of p65 PAK.
BLAST 'dvekrgsakellqhpflkl' with  or  |
| Reacts with
(species key) | Hu |
| Specificity | Displays some cross-reactivity with PAK2. |
| Tested applications
(see key) | WB |
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| Abreviews | |
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| Application notes
(see key) | Recommended dilutions
Reactive with p65PAK from diverse tissue sources by Western blotting.
Used at 1:100 with cell extracts.
Other immunodetection procedures not tested. |
| Positive control
(see definition) | HEK 293 whole cell lysate. |
| Cellular localization | Cytoplasm. Recruited to focal adhesions upon activation. |
| Research areas | Cancer >> Signal transduction >> Protein phosphorylation >> Serine/threonine kinases >> Other
Signal Transduction >> Protein Phosphorylation >> Ser / Thr Kinases >> Other Kinases
Cell Biology >> Apoptosis >> Intracellular >> Kinases |
| Relevance | The serine/threonine kinase Pak1 is an effector of small Rho GTPases, Rac1 and Cdc42. Pak1 complex specifically with Rac1 and Cdc42 in their active GTP bound state, inhibiting their intrinsic GTPase activity leading to their autophosphorylation. It plays an important role in the regulation of cell morphogenesis, motility, mitosis, and angiogenesis and has been implicated in the progression of many cancers. |
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| Database links | The links below go to external sites and will open in a new browser window |
| Raised in | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Purity | Immunogen affinity purified |
| Storage buffer | Preservative: 0.02% Sodium Azide
Constituents: PBS, pH 7.4 Material safety datasheet (MSDS) for this product:
Sodium Azide MSDS
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| Form | Liquid |
| Storage instructions | Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles. |
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At Abcam, we have one centralized database to hold all of our product information, so that everything we know about this PAK1 antibody is on this datasheet. But please do contact us if you would like any reassurance! |
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| See below for PAK1 antibody images, references, products related to ab1178 and other tools. |
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PAK1 antibody images: |
 Western blot - PAK1 antibody (ab1178)
ab1178 at a 1:100 dilution staining ~ 65 kDa p65 PAK in 10µg of HEK 293 cell lysate by western blot. ECL detection. |
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| Search PubMed (MEDLINE) for references to PAK1 |
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