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Products:Neuroscience >> Neurology process >> Neural Signal Transduction
Overview
Product name
Anti-PAK3 antibody
See all PAK3 products (6) ...
Description
Mouse monoclonal to PAK3
Tested applications
WB, ICC/IFmore details
Cross reactivity
Reacts with
Mouse, Human
Immunogen
Recombinant fragment: MSDGLDNEEK PPAPPLRMNS NNRDSSALNH SSKPLPMAPE EKNKKARLRS IFPGGGDKTN KKKEKERPEI SLPSDFEHTI HVGFDAVTGE , corresponding to amino acids 1-90 of Human PAK3
MSDGLDNEEK PPAPPLRMNS NNRDSSALNH SSKPLPMAPE EKNKKARLRS IFPGGGDKTN KKKEKERPEI SLPSDFEHTI HVGFDAVTGE
Properties
Form
Liquid
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Storage buffer
Preservative: None
PBS, pH 7.2
Concentration
Concentration information loading...
Purity
Protein G purified
Clonality
Monoclonal
Isotype
IgG2a
Light chain type
kappa
Research areas
Signal Transduction >> Signaling Pathway >> G Protein Signaling >> Small G Proteins >> Ras Family
Signal Transduction >> Signaling Pathway >> G Protein Signaling >> Small G Proteins >> Other
Signal Transduction >> Protein Phosphorylation >> Ser / Thr Kinases >> Other Kinases
Neuroscience >> Neurology process >> Neural Signal Transduction
Applications
Show applications key
Our Abpromise guarantee covers the use of ab58281 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
WB: Use a concentration of 1 - 5 µg/ml.Predicted molecular weight: 62 kDa.
ICC/IF: Use a concentration of 10 µg/ml
Target
Relevance
PAK proteins are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. PAK proteins serve as targets for the small GTP binding proteins Cdc42 and RAC and have been implicated in a wide range of biological activities. PAK3 forms an activated complex with GTP-bound RAS-like (P21), CDC2 and RAC1 proteins which then catalyzes a variety of targets. It may be necessary for dendritic development and for the rapid cytoskeletal reorganization in dendritic spines associated with synaptic plasticity. A point mutation in this gene has been linked to nonsyndromic X-linked mental retardation.
Cellular localization
Cytoplasmic
Alternative names
- Beta PAK antibody
- bPAK antibody
- CDKN1A antibody
see all
Database links
- Entrez Gene: 5063 Human
- Entrez Gene: 18481 Mouse
- Omim: 300142 Human
- SwissProt: O75914 Human
- SwissProt: Q17RE5 Human
- SwissProt: Q61036 Mouse
Anti-PAK3 antibody images:
Western blot - PAK3 antibody (ab58281)
PAK3 antibody (ab58281) at 1ug/lane + NIH/3T3 cell lysate at 25ug/lane.
Immunocytochemistry/ Immunofluorescence-PAK3 antibody(ab58281)
ab58281 at 10 ug/ml staining PAK3 in mouse NIH/3T3 cells by Immunocytochemistry/ Immunofluorescence.
References for Anti-PAK3 antibody (ab58281)
ab58281 has not yet been referenced specifically in any publications.
Publishing research using ab58281? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"