Anti-PAK4 antibody (ab126046)

Overview

• Product nameAnti-PAK4 antibodySee all PAK4 primary antibodies ...
• Description
  Rabbit polyclonal to PAK4
• Tested applicationsWB more details
• Species reactivity
  Reacts with: Human
  Predicted to work with: Mouse, Rat, Cow
• Immunogen

  Recombinant fragment, corresponding to a region within amino acids 208-472 of Human PAK4 (O96013).

• Positive controlNT2D1 and MCF7 whole cell lysates.
• General notesKeep as concentrated solution.

Properties

• FormLiquid
• Storage instructionsStore at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
• Storage bufferpH: 7.20
  Preservative: 0.01% Thimerosal (merthiolate)
  Constituents: 78% PBS, 20% Glycerol, 1% BSA
• Concentration information loading...
• PurityImmunogen affinity purified
• Clonality Polyclonal
• IsotypeIgG
• Research Areas
  • Cancer
  • Cell cycle
  • Kinases/phosphatases
  • Other

  • Signal Transduction
  • Cytoskeleton / ECM
  • Cytoskeleton
  • Microfilaments
  • Actin etc
  • Actin

  • Signal Transduction
  • Protein Phosphorylation
  • Ser / Thr Kinases
  • Other Kinases

  • Cell Biology
  • Apoptosis
  • Intracellular
  • Kinases

  • Cell Biology
  • Cell Cycle
  • Kinases/Phosphatases
  • Other

Applications

Target

• FunctionActivates the JNK pathway. Plays a role in the reorganization of the actin cytoskeleton and in the formation of filopodia. Phosphorylates and inactivates the protein phosphatase SSH1, leading to increased inhibitory phosphorylation of the actin binding/depolymerizing factor cofilin. Decreased cofilin activity may lead to stabilization of actin filaments. Phosphorylates ARHGEF2.
• Tissue specificityHighest expression in prostate, testis and colon.
• Sequence similaritiesBelongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
  Contains 1 CRIB domain.
  Contains 1 protein kinase domain.
• Post-translational
  modificationsAutophosphorylated on serine residues when activated by CDC42/p21.
  Phosphorylated on tyrosine residues upon stimulation of FGFR2.

Target information above from: UniProt accession O96013 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010) .

Information by UniProt
• Database links
  • Entrez Gene: 539742 Cow
  • Entrez Gene: 10298 Human
  • Entrez Gene: 70584 Mouse
  • Entrez Gene: 292756 Rat
  • Omim: 605451 Human
  • SwissProt: O96013 Human
  • SwissProt: Q8BTW9 Mouse
  • Unigene: 20447 Human

  • Unigene: 21876 Mouse
  • Unigene: 18543 Rat

  see all

• Alternative names
  KIAA1142 antibodyp21 activated kinase 4 antibodyp21(CDKN1A) activated kinase 4 antibody

  p21-activated kinase 4 antibodyPAK 4 antibodyPAK-4 antibodyPak4 antibodyPAK4_HUMAN antibodyProtein kinase related to S.cerevisiae STE20 effector for Cdc42Hs antibodySerine threonine kinase PAK 4 antibodySerine/threonine protein kinase PAK 4 antibodySerine/threonine protein kinase PAK4 antibodySerine/threonine-protein kinase PAK 4 antibody

  see all

Anti-PAK4 antibody images

• 

  Western blot - Anti-PAK4 antibody (ab126046)
  Anti-PAK4 antibody (ab126046) at 1/500 dilution + NT2D1 whole cell lysate at 30 µg
  
  Predicted band size : 64 kDa