Overview
Product namePALB2 peptideSee all PALB2 proteins and peptides ...
Protein descriptionSynthetic peptide conjugated to KLH derived from within residues 450 - 550 of Human PALB2.(Note: the amino acid sequence is proprietary)This peptide was used as an immunogen for ab38742 - PALB2 antibody.
Protein length1186 amino acids
Properties
FormLiquid
Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Storage bufferInformation available upon request.
Concentration information loading...
Research Areas
Applications
Application notesThis peptide can be used with studies using ab38587 and ab38742.
Protein info
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Alternative names
4732427B05BC066140DKFZp667I166
DKFZp686E1054FANCNFANCN GENEFLJ21816OTTMUSP00000025884PALB2PALB2_HUMANpartner and localizer of BRCA2PNCA3RGD1304759
see all
FunctionPlays a critical role in homologous recombination repair (HRR) through its ability to recruit BRCA2 and RAD51 to DNA breaks. Serves as the molecular scaffold in the formation of the BRCA1-PALB2-BRCA2 complex which is essential for homologous recombination. Strongly stimulates the DNA strand-invasion activity of RAD51, stabilizes the nucleoprotein filament against a disruptive BRC3-BRC4 polypeptide and helps RAD51 to overcome the suppressive effect of replication protein A (RPA). Functionally cooperates with RAD51AP1 in promoting of D-loop formation by RAD51. Essential partner of BRCA2 that promotes the localization and stability of BRCA2. Also enables its recombinational repair and checkpoint functions of BRCA2. May act by promoting stable association of BRCA2 with nuclear structures, allowing BRCA2 to escape the effects of proteasome-mediated degradation. Binds DNA with high affinity for D loop, which comprises single-stranded, double-stranded and branched DNA structures.
Involvement in diseaseNote=Genetic variations in PALB2 are associated with breast cancer susceptibility.
Defects in PALB2 are the cause of Fanconi anemia complementation group N (FANCN) [MIM:610832]. It is a disorder affecting all bone marrow elements and resulting in anemia, leukopenia and thrombopenia. It is associated with cardiac, renal and limb malformations, dermal pigmentary changes, and a predisposition to the development of malignancies. At the cellular level it is associated with hypersensitivity to DNA-damaging agents, chromosomal instability (increased chromosome breakage) and defective DNA repair.
Defects in PALB2 are the cause of pancreatic cancer type 3 (PNCA3) [MIM:613348]. It is a malignant neoplasm of the pancreas. Tumors can arise from both the exocrine and endocrine portions of the pancreas, but 95% of them develop from the exocrine portion, including the ductal epithelium, acinar cells, connective tissue, and lymphatic tissue.
Sequence similaritiesContains 7 WD repeats.
DomainInteraction with BRCA2 occurs through a hydrophobic pocket at the crossover between WD repeats 4 and 5.
Post-translational
modificationsPhosphorylated upon DNA damage, probably by ATM or ATR.
Cellular localizationNucleus. Colocalizes with BRCA2 in nuclear foci.
References for PALB2 peptide (ab38741)
ab38741
has not yet been referenced specifically in any publications.
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"
