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Products:Cardiovascular >> Blood >> Serum Proteins
Overview
Product name
Anti-PAPP A antibody [10A5]
See all PAPP A products (17) ...
Description
Mouse monoclonal [10A5] to PAPP A
Tested applications
ELISA, WB, Sandwich ELISAmore details
Cross reactivity
Reacts with
Human
Immunogen
Purified human PAPPA antigen.
General notes
Concentration varies from lot to lot and can be provided on request.
Properties
Form
Liquid
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Storage buffer
Preservative: 0.1% Sodium Azide
Constituents: PBS, pH 7.4
Concentration
Concentration information loading...
Purity
Protein A purified
Purification notes
Purified by chromatography on protein A sepharose. Purity tested by electrophoresis.
Clonality
Monoclonal
Clone number
10A5
Myeloma
Sp2/0
Isotype
IgG2a
Research areas
Cell Biology >> Other Antibodies >> Other Antibodies
Cardiovascular >> Blood >> Serum Proteins
Applications
Show applications key
Our Abpromise guarantee covers the use of ab10193 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
ELISA: Use at an assay dependent dilution.
WB: Use at an assay dependent dilution. Detects a band of approximately 500 kDa.
sELISA: Use at an assay dependent dilution.
Target
Function
Metalloproteinase which specifically cleaves IGFBP-4 and IGFBP-5, resulting in release of bound IGF. Cleavage of IGFBP-4 is dramatically enhanced by the presence of IGF, whereas cleavage of IGFBP-5 is slightly inhibited by the presence of IGF.
Tissue specificity
High levels in placenta and pregnancy serum. In placenta, expressed in X cells in septa and anchoring villi, and in syncytiotrophoblasts in the chorionic villi. Lower levels are found in a variety of other tissues including kidney, myometrium, endometrium, ovaries, breast, prostate, bone marrow, colon, fibroblasts and osteoblasts.
Sequence similarities
Belongs to the peptidase M43B family.
Contains 5 Sushi (CCP/SCR) domains.
Developmental stage
Present in serum and placenta during pregnancy; levels increase throughout pregnancy.
Post-translational
modifications
There appear to be no free sulfhydryl groups.
Cellular localization
Secreted.
Target information above from: UniProt accessionQ13219
The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).
Alternative names
- ASBABP2 antibody
- Aspecific BCL2 ARE binding protein 2 antibody
- Differentially placenta 1 expressed protein antibody
see all
Database links
- Entrez Gene: 5069 Human
- Omim: 176385 Human
- SwissProt: Q13219 Human
- Unigene: 643599 Human
- Unigene: 728832 Human
References for Anti-PAPP A antibody [10A5] (ab10193)
ab10193 has not yet been referenced specifically in any publications.
Publishing research using ab10193? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"