Anti-PARL antibody [8C4B2;1H12E10] (ab130190)

Overview

  • Product nameAnti-PARL antibody [8C4B2;1H12E10]See all PARL primary antibodies ...
  • Description
    Mouse monoclonal [8C4B2;1H12E10] to PARL
  • Tested applicationsWB, ELISA more details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat, Rabbit, Horse, Cow, Dog, Pig, Chimpanzee
  • Immunogen

    Purified recombinant fragment: AFGSAAIWQY ESLKSRVQSY FDGIKADWLD SIRPQKEGDF RKEINKWWNN LSDGQR, corresponding to amino acids 112-167 of Human PARL expressed in E. coli.

Properties

Applications

Our Abpromise guarantee covers the use of ab130190 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Notes
WB 1/500 - 1/2000. Predicted molecular weight: 42 kDa.
ELISA 1/10000.

Target

  • FunctionRequired for the control of apoptosis during postnatal growth. Essential for proteolytic processing of an antiapoptotic form of OPA1 which prevents the release of mitochondrial cytochrome c in response to intrinsic apoptoptic signals (By similarity). Promotes changes in mitochondria morphology regulated by phosphorylation of P-beta domain.
  • Sequence similaritiesBelongs to the peptidase S54 family.
  • Post-translational
    modifications
    P-beta is proteolytically processed (beta-cleavage) in a PARL-dependent manner. The cleavage is inhibited when residues Ser-65, Thr-69 and Ser-70 are all phosphorylated.
  • Cellular localizationMitochondrion inner membrane and Nucleus. Translocated into the nucleus by an unknown mechanism.
  • Target information above from: UniProt accession Q9H300 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt
  • Database links
  • Alternative names
    • Mitochondrial intramembrane cleaving protease PARL antibody
    • Mitochondrial intramembrane-cleaving protease PARL antibody
    • P-beta antibody
    • parl antibody
    • PARL_HUMAN antibody
    • Pbeta antibody
    • presenilin associated rhomboid-like antibody
    • Presenilins associated rhomboid-like protein antibody
    • PRO2207 antibody
    • PSARL antibody
    • PSARL1 antibody
    • PSENIP2 antibody
    • RHBDS1 antibody
    • Rhomboid 7 homolog 1 antibody
    see all

Anti-PARL antibody [8C4B2;1H12E10] images

  • All lanes : Anti-PARL antibody [8C4B2;1H12E10] (ab130190) at 1/500 dilution

    Lane 1 : Truncated Trx-PARL recombinant protein
    Lane 2 : Truncated MBP-PARL (aa112-167) recombinant protein


    Predicted band size : 42 kDa

References for Anti-PARL antibody [8C4B2;1H12E10] (ab130190)

ab130190 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"