Anti-PARL antibody [8C4B2;1H12E10] (ab130190)
- Product nameAnti-PARL antibody [8C4B2;1H12E10]See all PARL primary antibodies ...
- DescriptionMouse monoclonal [8C4B2;1H12E10] to PARL
- Tested applicationsWB, ELISA more details
- Species reactivityReacts with: Human
Predicted to work with: Mouse, Rat, Rabbit, Horse, Cow, Dog, Pig, Chimpanzee
Purified recombinant fragment: AFGSAAIWQY ESLKSRVQSY FDGIKADWLD SIRPQKEGDF RKEINKWWNN LSDGQR, corresponding to amino acids 112-167 of Human PARL expressed in E. coli.
- Storage instructionsStore at 4°C or at -20°C for long term storage.
- Storage bufferPreservative: 0.03% Sodium azide
- Concentration information loading...
- Clonality Monoclonal
- Clone number8C4B2;1H12E10
Our Abpromise guarantee covers the use of ab130190 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|WB||WB: 1/500 - 1/2000. Predicted molecular weight: 42 kDa.|
- FunctionRequired for the control of apoptosis during postnatal growth. Essential for proteolytic processing of an antiapoptotic form of OPA1 which prevents the release of mitochondrial cytochrome c in response to intrinsic apoptoptic signals (By similarity). Promotes changes in mitochondria morphology regulated by phosphorylation of P-beta domain.
- Sequence similaritiesBelongs to the peptidase S54 family.
modificationsP-beta is proteolytically processed (beta-cleavage) in a PARL-dependent manner. The cleavage is inhibited when residues Ser-65, Thr-69 and Ser-70 are all phosphorylated.
- Cellular localizationMitochondrion inner membrane and Nucleus. Translocated into the nucleus by an unknown mechanism.
- Entrez Gene: 460877 Chimpanzee
- Entrez Gene: 514191 Cow
- Entrez Gene: 488100 Dog
- Entrez Gene: 100058851 Horse
- Entrez Gene: 55486 Human
- Entrez Gene: 381038 Mouse
- Entrez Gene: 287979 Rat
- Omim: 607858 Human
- SwissProt: Q2KHV4 Cow
- SwissProt: Q9H300 Human
- SwissProt: Q5XJY4 Mouse
- SwissProt: Q3B8P0 Rat
- Unigene: 478469 Human
- Unigene: 371737 Mouse
- Unigene: 7053 Rat
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- PSARL antibody
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Anti-PARL antibody [8C4B2;1H12E10] images
All lanes : Anti-PARL antibody [8C4B2;1H12E10] (ab130190) at 1/500 dilution
Lane 1 : Truncated Trx-PARL recombinant protein
Lane 2 : Truncated MBP-PARL (aa112-167) recombinant protein
Predicted band size : 42 kDa
References for Anti-PARL antibody [8C4B2;1H12E10] (ab130190)
ab130190 has not yet been referenced specifically in any publications.