Anti-PARP3 antibody (ab110154)

Overview

• Product nameAnti-PARP3 antibodySee all PARP3 primary antibodies ...
• Description
  Goat polyclonal to PARP3
• Tested applicationsIHC-P more details
• Species reactivity
  Reacts with: Human
  
• Immunogen

  Synthetic peptide: YEDYNCTLNQTNIEN, corresponding to internal sequence amino acids 63-77 of Human PARP3 (NP_001003931.2; NP_001003935.2)

  Run BLAST with Run BLAST with
• Positive controlHuman kidney and liver tissue.

Properties

• FormLiquid
• Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
• Storage bufferpH: 7.30
  Preservative: 0.02% Sodium azide
  Constituents: Tris buffered saline, 0.5% BSA
• Concentration information loading...
• PurityImmunogen affinity purified
• Clonality Polyclonal
• IsotypeIgG
• Research Areas
  • Epigenetics and Nuclear Signaling
  • Chromatin Modifying Enzymes
  • ADP-ribosylation

  • Epigenetics and Nuclear Signaling
  • DNA / RNA
  • DNA Damage & Repair
  • DNA Damage Response
  • DNA Damage Recognition

  • Cell Biology
  • Apoptosis
  • Nucleus
  • PARP

Applications

Target

• FunctionInvolved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks. May link the DNA damage surveillance network to the mitotic fidelity checkpoint. Negatively influences the G1/S cell cycle progression without interfering with centrosome duplication. Binds DNA. May be involved in the regulation of PRC2 and PRC3 complex-dependent gene silencing.
• Tissue specificityWidely expressed; the highest levels are in the kidney, skeletal muscle, liver, heart and spleen; also detected in pancreas, lung, placenta, brain, leukocytes, colon, small intestine, ovary, testis, prostate and thymus.
• Sequence similaritiesContains 1 PARP alpha-helical domain.
  Contains 1 PARP catalytic domain.
• DomainAccording to PubMed:10329013, the N-terminal domain (54 amino acids) of isoform 2 is responsible for its centrosomal localization. The C-terminal region contains the catalytic domain.
• Post-translational
  modificationsAuto-poly(ADP)-ribosylation.
• Cellular localizationNucleus. Cytoplasm > cytoskeleton > centrosome. Cytoplasm > cytoskeleton > centrosome > centriole. Core component of the centrosome. Preferentially localized to the daughter centriole throughout the cell cycle. According to PubMed:16924674, it is almost exclusively localized in the nucleus and appears in numerous small foci and a small number of larger foci whereas a centrosomal location has not been detected.

Target information above from: UniProt accession Q9Y6F1 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010) .

Information by UniProt
• Database links
  • Entrez Gene: 10039 Human
  • Entrez Gene: 10039 Human
  • Omim: 607726 Human
  • SwissProt: Q9Y6F1 Human
  • SwissProt: Q9Y6F1 Human
  • Unigene: 271742 Human

• Alternative names
  ADP ribosyltransferase (NAD+; poly (ADP ribose) antibodyADPRT-3 antibodyADPRT3 antibody

  ADPRTL2 antibodyADPRTL3 antibodyhPARP 3 antibodyhPARP-3 antibodyhPARP3 antibodyIRT 1 antibodyIRT1 antibodyIRT1 antibodyNAD(+) ADP ribosyltransferase 3 antibodyNAD(+) ADP-ribosyltransferase 3 antibodyNAD+ ADP ribosyltransferase 3 antibodypADPRT 3 antibodypADPRT-3 antibodypADPRT3 antibodyPARP 3 antibodyPARP-3 antibodyPARP3 antibodyPARP3_HUMAN antibodyPoly (ADP ribose) polymerase family, member 3 antibodyPoly (ADP ribose) synthetase 3 antibodyPoly [ADP-ribose] polymerase 3 antibodyPoly[ADP ribose] synthetase 3 antibodyPoly[ADP-ribose] synthase 3 antibody

  see all

Anti-PARP3 antibody images

• 

  Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - PARP3 antibody (ab110154)
  Immunohistochemical analysis of Formalin-Fixed, Paraffin-Embedded Human Kidney using ab110154 at 3.75µg/ml.
• 

  Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - PARP3 antibody (ab110154)
  Immunohistochemical analysis of Formalin-Fixed, Paraffin-Embedded Human Liver using ab110154 at 3.75µg/ml