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Overview
Product name
Anti-PAX5 antibody
See all PAX5 products (15) ...
Description
Mouse monoclonal to PAX5
Tested applications
WB, IHC-Pmore details
Cross reactivity
Reacts with
Human
Immunogen
Recombinant fragment, corresponding to amino acids 192-302 of Human PAX5
Properties
Form
Liquid
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Storage buffer
Preservative: None
PBS, pH 7.2
Concentration
Concentration information loading...
Purity
Protein G purified
Clonality
Monoclonal
Isotype
IgG1
Light chain type
kappa
Research areas
Epigenetics and Nuclear Signaling >> Transcription >> Domain Families >> Developmental Families >> PAX
Neuroscience >> Neurology process >> Neurogenesis
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IHC-P - PAX5 antibody (ab55492)
(enlarge)
Applications
Show applications key
Our Abpromise guarantee covers the use of ab55492 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
WB
- 1 Image
IHC-P
Application notes
WB: Use at a concentration of 1-5 µg/ml.
IHC-P: Use at a concentration of 1 µg/ml.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
Target
Function
May play an important role in B-cell differentiation as well as neural development and spermatogenesis. Involved in the regulation of the CD19 gene, a B-lymphoid-specific target gene.
Involvement in disease
Note=A chromosomal aberration involving PAX5 is a cause of acute lymphoblastic leukemia. Translocation t(9;18)(p13;q11.2) with ZNF521. Translocation t(9;3)(p13;p14.1) with FOXP1. Translocation t(9;12)(p13;p13) with ETV6.
Sequence similarities
Contains 1 paired domain.
Developmental stage
Expressed at early B-cell differentiation, in the developing CNS and in adult testis.
Post-translational
modifications
O-glycosylated.
Cellular localization
Nucleus.
Target information above from: UniProt accessionQ02548
The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).
Alternative names
- B cell lineage specific activator antibody
- B cell lineage specific activator protein antibody
- B cell specific activator protein antibody
see all
Database links
- Entrez Gene: 5079 Human
- Omim: 167414 Human
- SwissProt: Q02548 Human
- Unigene: 654464 Human
Anti-PAX5 antibody images:
IHC-P - PAX5 antibody (ab55492)
PAX5 antibody (ab55492) used in immunohistochemistry at 1ug/ml on formalin fixed and paraffin embedded human tonsil.
References for Anti-PAX5 antibody (ab55492)
ab55492 has not yet been referenced specifically in any publications.
Publishing research using ab55492? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"