Anti-CBX4 antibody (ab38430)

Overview

• Product nameAnti-CBX4 antibodySee all CBX4 primary antibodies ...
• Description
  Rabbit polyclonal to CBX4
• Tested applicationsELISA, WB more details
• Species reactivity
  Reacts with: Human
  
• Immunogen

  KLH-conjugated synthetic peptide from within aa 400~450 of human PC2.

Properties

• FormLiquid
• Storage instructionsStore at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze / thaw cycles.
• Storage bufferPreservative: 0.09% Sodium Azide
  Constituents: PBS
• Concentration information loading...
• PurityProtein G purified
• Clonality Polyclonal
• IsotypeIgG
• Research Areas
  • Epigenetics and Nuclear Signaling
  • Chromatin Remodeling
  • Polycomb Silencing
  • Other

  • Epigenetics and Nuclear Signaling
  • Chromatin Binding Proteins
  • Methylated DNA

  • Epigenetics and Nuclear Signaling
  • Ubiquitin & Ubiquitin Like Modifiers
  • Ubiquitin like Modifiers

  • Epigenetics and Nuclear Signaling
  • Chromatin Remodeling
  • Polycomb Silencing
  • PRC2

Applications

Target

• FunctionE3 SUMO-protein ligase which facilitates SUMO1 conjugation by UBE2I. Component of the Polycomb group (PcG) multiprotein PRC1 complex, a complex required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility.
• Tissue specificityUbiquitous.
• PathwayProtein modification; protein sumoylation.
• Sequence similaritiesContains 1 chromo domain.
• Post-translational
  modificationsPhosphorylated on Thr-497 by HIPK2 upon DNA damage; which enhances E3 SUMO-protein ligase activity and promotes sumoylation on Lys-494.
• Cellular localizationNucleus.

Target information above from: UniProt accession O00257 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010) .

Information by UniProt
• Database links
  • Entrez Gene: 8535 Human
  • Omim: 603079 Human
  • SwissProt: O00257 Human
  • Unigene: 743401 Human

• Alternative names
  CBX 4 antibodyCBX4 antibodyCbx4 chromobox homolog 4 (Drosophila Pc class) antibody

  Cbx4: chromobox homolog 4 (Drosophila Pc class) antibodyCBX4_HUMAN antibodyChromobox homolog 4 (Pc class homolog, Drosophila) antibodyChromobox homolog 4 antibodyChromobox protein homolog 4 antibodyE3 SUMO protein ligase CBX 4 antibodyE3 SUMO protein ligase CBX4 antibodyE3 SUMO-protein ligase CBX4 antibodyhPc 2 antibodyhPc2 antibodyNBP 16 antibodyNBP16 antibodyNS5ATP1 binding protein 16 antibodyPc 2 antibodyPc class 2 homolog antibodyPc class homolog antibodyPc class homolog Drosophila antibodyPc2 antibodyPolycomb 2 homolog antibody

  see all

Anti-CBX4 antibody images

• 

  Western blot - PC2 antibody (ab38430)
  Anti-CBX4 antibody (ab38430) at 1/100 dilution + Jurkat cell lysate
  
  Predicted band size : 61 kDa