PC6 antibody - Aminoterminal end (ab39873)

Product Name 

PC6 antibody - Aminoterminal end

Product type 

Primary antibodies

Description 

Rabbit polyclonal to PC6 - Aminoterminal end

Immunogen 

Synthetic peptide corresponding to the amino end of mature Human PC6.

(Peptide available as ab41413.)

Reacts with 
(species key)

Hu, Ms, Rat

Specificity 

ab39873 recognizes the Amino end of the mature enzyme subtilisin like serine protease PC6.

We have a range of domain specific antibodies for this target. For a full list please see all PC6 antibodies

Tested applications 
(see key)

IHC-P, WB

Abreviews 

Customer reviews (see key)

Read about Abreviews

Application notes 
(see key)

Recommended dilutions
IHC-P: 1/500 (PMID 19339735).
WB: 1/1000 - 1/5000. Predicted molecular weight: 101 kDa.


Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.

Cellular localization 

Secreted

Research areas 

Cell Biology >> Proteolysis / Ubiquitin >> Proteolytic enzymes >> Serine protease >> Proprotein Convertases

Chromatin and Nuclear Signaling >> DNA / RNA >> Translation >> ER Translocation

Relevance 

PC6 (or PC5) belongs to the subtilisin-like proprotein convertase family. The members of this family are proprotein convertases that process latent precursor proteins into their biologically active products. PC6 mediates posttranslational endoproteolytic processing for several integrin alpha subunits. It is thought to process prorenin, pro-membrane type 1 matrix metalloproteinase and HIV1 glycoprotein gp160. Two splice variants are reported; the original 913 amino acid sequence (PC5A) and an 1877 amino acid membrane-associated form (PC5B). The longer form is thought to be bound in the Golgi, and the shorter form secreted through dense core secretory granules. PC6 has been shown to cleave the neural adhesion protein L1, Preo-neurotension, VEGF-C, Integrin alpha V, some viral surface proteins, and is thought to process prorenin. Like furin, PC2 and PACE4, PC6 is a serine proteinase that cleaves after pairs of basic amino acids, but with some differences in substrate specificity and distribution.

Database links 

Raised in 

Rabbit

Clonality 

Polyclonal

Isotype 

IgG

Purity 

Immunogen affinity purified

Storage buffer 

Preservative: 0.05% Sodium Azide
Constituents: 50% Glycerol, PBS, 500mM Sodium chloride, pH 7.4

Material safety datasheets (MSDS) for this product:
Glycerol MSDS
Sodium Azide MSDS

Form 

Liquid

Concentration 

1.000 mg/ml

Storage instructions 

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

References for PC6 antibody - Aminoterminal end (ab39873)

  This product has been used in:

Fuller JA et al. Subtilisin-like proprotein convertase expression, localization, and activity in the human retina and optic nerve head. Invest Ophthalmol Vis Sci 50:5759-68 (2009). IHC-P; Human. PubMed: 19339735

If you publish research using ab39873 please let us know so that we can cite the reference on this datasheet.

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