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Product Name
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PC6 peptide (Aminoterminal end)
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Product type
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Proteins and Peptides
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Peptide
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Synthetic peptide PC6.
This peptide was used as an immunogen for ab39873 - PC6 antibody.
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Specificity
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We have a range of domain specific antibodies for this target. For a full list please see all PC6 antibodies
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Tested applications
(see key)
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ELISA, WB
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Application notes
(see key)
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Recommended dilutions
ELISA: Use at an assay dependent dilution. WB: Use at an assay dependent dilution. This peptide can be used with studies using ab39873. Dilution optimised using Chromogenic detection. Not yet tested in other applications. Optimal dilutions/concentrations should be determined by the end user.
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Research areas
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Cell Biology >> Proteolysis / Ubiquitin >> Proteolytic enzymes >> Serine protease >> Proprotein Convertases
Chromatin and Nuclear Signaling >> DNA / RNA >> Translation >> ER Translocation
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Relevance
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PC6 (or PC5) belongs to the subtilisin-like proprotein convertase family. The members of this family are proprotein convertases that process latent precursor proteins into their biologically active products. PC6 mediates posttranslational endoproteolytic processing for several integrin alpha subunits. It is thought to process prorenin, pro-membrane type 1 matrix metalloproteinase and HIV1 glycoprotein gp160. Two splice variants are reported; the original 913 amino acid sequence (PC5A) and an 1877 amino acid membrane-associated form (PC5B). The longer form is thought to be bound in the Golgi, and the shorter form secreted through dense core secretory granules. PC6 has been shown to cleave the neural adhesion protein L1, Preo-neurotension, VEGF-C, Integrin alpha V, some viral surface proteins, and is thought to process prorenin. Like furin, PC2 and PACE4, PC6 is a serine proteinase that cleaves after pairs of basic amino acids, but with some differences in substrate specificity and distribution.
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PC6 peptide (Aminoterminal end) (ab41413) |
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Purity
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>95% by SDS-PAGE
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Storage buffer
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Preservative: None
Constituents: 0.001% Tween 20, 30mM HEPES, 2mM EDTA, 150mM Sodium chloride, pH 6.75
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Form
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Liquid
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Concentration
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1.000 mg/ml
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Storage instructions
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Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
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At Abcam, we have one centralized database to hold all of our product information, so that everything we know about this PC6 peptide (Aminoterminal end) is on this datasheet. But please do contact us if you would like any reassurance! |
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Search PubMed (MEDLINE) for references to PC6
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PC6 peptide (Aminoterminal end) - more information
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All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"
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