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Overview

  • Product namePC6 proteinSee all PC6 proteins and peptides ...
  • Protein descriptionRecombinant fragment corresponding to amino acids 804-913 of Human PC6 with an N terminal proprietary tag; Predicted MWt 37.73 kDa (NP_006191.2).
  • Uniprot accessionQ92824
  • Molecular weight37.730kDa inclusive of tags
  • Protein length110 amino acids
  • Expression hostWheat germ

    • Properties

  • E.C. Number3.4.21.-
  • FormLiquid
  • Storage instructionsShipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.
  • Storage bufferpH: 8.00
    Constituents: 0.3% Glutathione, 0.79% Tris HCl
  • Concentration information loading...
  • Additional notesProtein concentration is above or equal to 0.05 mg/ml.
    Best used within three months from the date of receipt.
  • Sequence notesTEGYFMEDGRCVQSCSISYYFDHSSENGYKSCKKCDISCL TCNGPGFKNCTSCPSGYLLDLGMCQMGAICKDATEESWAE GGFCMLVKKNNLCQRKVLQQLCCKTCTFQG
  • Research Areas

    • Applications

    Our Abpromise guarantee covers the use of ab114944 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    Application Notes
    ELISA ELISA: Use at an assay dependent concentration.
    SDS-PAGE SDS-PAGE: Use at an assay dependent concentration.
    WB WB: Use at an assay dependent concentration. (Recombinant protein).

    Protein info

    • Alternative names
        FLJ11149FLJ16215hPC6
        PC5PC6PC6APcsk5PCSK5_HUMANProhormone convertase 5Proprotein convertase 5Proprotein convertase 6Proprotein convertase PC5Proprotein convertase subtilisin/kexin type 5Protease PC6SPC6Subtilisin/kexin-like protease PC5
      see all
  • FunctionLikely to represent a widespread endoprotease activity within the constitutive and regulated secretory pathway. Capable of cleavage at the RX(K/R)R consensus motif.
  • Tissue specificityExpressed in T-lymphocytes.
  • Sequence similaritiesBelongs to the peptidase S8 family.
    Contains 1 homo B/P domain.
    Contains 1 PLAC domain.
  • DomainThe propeptide domain acts as an intramolecular chaperone assisting the folding of the zymogen within the endoplasmic reticulum.
  • Cellular localizationSecreted.

    • Target information above from: UniProt accession Q92824 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt

    PC6 protein images

    • SDS-PAGE - PC6 protein (ab114944)
      SDS-PAGE - PC6 protein (ab114944)
      ab114944 analyzed on a 12.5% SDS-PAGE gel stained with Coomassie Blue.

    References for PC6 protein (ab114944)

    ab114944 has not yet been referenced specifically in any publications.

    Publishing research using ab114944 ? Please let us know so that we can cite the reference in this datasheet

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